Microvascular density, CD68 and tryptase expression in human Diffuse Large B-Cell Lymphoma

Christian Marinaccio, Giuseppe Ingravallo, Francesco Gaudio, Tommasina Perrone, Beatrice Nico, Eugenio Maoirano, Giorgina Specchia, Domenico Ribatti

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Diffuse Large B-cell Lymphoma (DLBCL) is the most common form of Non-Hodgkin lymphoma characterized by clinical and biological heterogeneity attributable both to the tumor cells and the complex tumor-microenvironment surrounding them. Tumor-associated macrophages (TAMs) and mast cells are two major components of the tumor inflammatory infiltrate with a definite role in enhancing tumor angiogenesis. In this study, we have investigated CD68 and tryptase expression and their relationship with microvascular density (MVD) in chemo-resistant and chemosensitive patients affected by DLBCL. CD68 and tryptase expression as well as MVD were increased in chemo-resistant patients when compared with chemosensitive patients. Tryptase expression showed a positive correlation with MVD, supporting a role for mast cell in DLBCL tumor angiogenesis, while CD68 correlation with MVD was not significant, indicating a different role for TAMs than angiogenesis in DLBCL.

Original languageEnglish
Pages (from-to)1374-1377
Number of pages4
JournalLeukemia Research
Volume38
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Tryptases
Lymphoma, Large B-Cell, Diffuse
Neoplasms
Mast Cells
Macrophages
Tumor Microenvironment
Non-Hodgkin's Lymphoma

Keywords

  • Diffuse Large B-Cell Lymphoma
  • Macrophages
  • Mast cells
  • Microvascular density

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology
  • Medicine(all)

Cite this

Marinaccio, C., Ingravallo, G., Gaudio, F., Perrone, T., Nico, B., Maoirano, E., ... Ribatti, D. (2014). Microvascular density, CD68 and tryptase expression in human Diffuse Large B-Cell Lymphoma. Leukemia Research, 38(11), 1374-1377. https://doi.org/10.1016/j.leukres.2014.09.007

Microvascular density, CD68 and tryptase expression in human Diffuse Large B-Cell Lymphoma. / Marinaccio, Christian; Ingravallo, Giuseppe; Gaudio, Francesco; Perrone, Tommasina; Nico, Beatrice; Maoirano, Eugenio; Specchia, Giorgina; Ribatti, Domenico.

In: Leukemia Research, Vol. 38, No. 11, 01.11.2014, p. 1374-1377.

Research output: Contribution to journalArticle

Marinaccio, C, Ingravallo, G, Gaudio, F, Perrone, T, Nico, B, Maoirano, E, Specchia, G & Ribatti, D 2014, 'Microvascular density, CD68 and tryptase expression in human Diffuse Large B-Cell Lymphoma', Leukemia Research, vol. 38, no. 11, pp. 1374-1377. https://doi.org/10.1016/j.leukres.2014.09.007
Marinaccio C, Ingravallo G, Gaudio F, Perrone T, Nico B, Maoirano E et al. Microvascular density, CD68 and tryptase expression in human Diffuse Large B-Cell Lymphoma. Leukemia Research. 2014 Nov 1;38(11):1374-1377. https://doi.org/10.1016/j.leukres.2014.09.007
Marinaccio, Christian ; Ingravallo, Giuseppe ; Gaudio, Francesco ; Perrone, Tommasina ; Nico, Beatrice ; Maoirano, Eugenio ; Specchia, Giorgina ; Ribatti, Domenico. / Microvascular density, CD68 and tryptase expression in human Diffuse Large B-Cell Lymphoma. In: Leukemia Research. 2014 ; Vol. 38, No. 11. pp. 1374-1377.
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