Microvascular inflammation in atherosclerosis

Laura Vitiello, Ilaria Spoletini, Stefania Gorini, Laura Pontecorvo, Davide Ferrari, Elisabetta Ferraro, Eugenio Stabile, Massimiliano Caprio, Andrea La Sala

Research output: Contribution to journalArticlepeer-review

Abstract

Atherogenesis is the pathogenetic process leading to formation of the atheroma lesion. It is associated to a chronic inflammatory state initially stimulated by an aberrant accumulation of lipid molecules beyond the endothelial barrier. This event triggers a cascade of deleterious events mainly through immune cell stimulation with the consequent liberation of potent pro-inflammatory and tissue damaging mediators. The atherogenetic process implies marked modifications of endothelial cell functions and a radical change in the endothelial-leukocyte interaction pattern. Moreover, accumulating evidence shows an important link between microvascular and inflammatory responses and major cardiovascular risk factors. This review illustrates the current knowledge on the effects of obesity, hypercholesterolemia and diabetes on microcirculation; their pathophysiological implications will be discussed.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalIJC Metabolic and Endocrine
Volume3
DOIs
Publication statusPublished - 2014

Keywords

  • Atherosclerosis
  • Inflammation
  • Microcirculation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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