Microvascular invasion and grading in hepatocellular carcinoma: correlation with major and ancillary features according to LIRADS

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Abstract

Purpose: To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC. Materials and methods: In this retrospective study, we assessed 62 patients (14 women–48 men; mean age, 63 years; range 38–80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected. Results: No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV. Conclusion: Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.

Original languageEnglish
JournalAbdominal Radiology
DOIs
Publication statusPublished - Jan 1 2019

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Hepatocellular Carcinoma
Multidetector Computed Tomography
Magnetic Resonance Spectroscopy
Multivariate Analysis
Retrospective Studies
Regression Analysis
Liver
Radiologists

Keywords

  • Hepatocellular carcinoma
  • Histological grading
  • Magnetic resonance imaging
  • Microvascular invasion
  • Multidetector computed tomography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

Cite this

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title = "Microvascular invasion and grading in hepatocellular carcinoma: correlation with major and ancillary features according to LIRADS",
abstract = "Purpose: To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC. Materials and methods: In this retrospective study, we assessed 62 patients (14 women–48 men; mean age, 63 years; range 38–80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected. Results: No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV. Conclusion: Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.",
keywords = "Hepatocellular carcinoma, Histological grading, Magnetic resonance imaging, Microvascular invasion, Multidetector computed tomography",
author = "Vincenza Granata and Roberta Fusco and Setola, {Sergio Venanzio} and Carmine Picone and Paolo Vallone and Andrea Belli and Paola Incollingo and Vittorio Albino and Fabiana Tatangelo and Francesco Izzo and Antonella Petrillo",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00261-019-02056-6",
language = "English",
journal = "Abdominal Radiology",
issn = "2366-004X",
publisher = "Springer New York",

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TY - JOUR

T1 - Microvascular invasion and grading in hepatocellular carcinoma

T2 - correlation with major and ancillary features according to LIRADS

AU - Granata, Vincenza

AU - Fusco, Roberta

AU - Setola, Sergio Venanzio

AU - Picone, Carmine

AU - Vallone, Paolo

AU - Belli, Andrea

AU - Incollingo, Paola

AU - Albino, Vittorio

AU - Tatangelo, Fabiana

AU - Izzo, Francesco

AU - Petrillo, Antonella

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC. Materials and methods: In this retrospective study, we assessed 62 patients (14 women–48 men; mean age, 63 years; range 38–80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected. Results: No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV. Conclusion: Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.

AB - Purpose: To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC. Materials and methods: In this retrospective study, we assessed 62 patients (14 women–48 men; mean age, 63 years; range 38–80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected. Results: No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV. Conclusion: Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.

KW - Hepatocellular carcinoma

KW - Histological grading

KW - Magnetic resonance imaging

KW - Microvascular invasion

KW - Multidetector computed tomography

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