Microvesicles: What is the role in multiple sclerosis?

Tiziana Carandini, Federico Colombo, Annamaria Finardi, Giacomo Casella, Livia Garzetti, Claudia Verderio, Roberto Furlan

Research output: Contribution to journalArticlepeer-review

Abstract

Microvesicles are a recently described way of cell communication that has been implicated in a number of biological processes, including neuroinflammation. Widely investigated as biomarkers in oncology and neurological disorders, little is known of the role of microvesicles in the pathogenesis of diseases such as multiple sclerosis (MS). Several evidences suggest that pro-inflammatory microglia and infiltrating macrophages release microvesicles that spread inflammatory signals and alter neuronal functions. We review here available information on microvesicles, with a special focus on microglia and macrophage microvesicles, in the pathogenesis of MS, and as potential biomarkers and therapeutic targets.

Original languageEnglish
Article number00111
JournalFrontiers in Neurology
Volume6
Issue numberMAY
DOIs
Publication statusPublished - 2015

Keywords

  • Biomarkers
  • Ectosomes
  • Exosomes
  • Horizontal communication
  • Microglia
  • Microvesicles
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint

Dive into the research topics of 'Microvesicles: What is the role in multiple sclerosis?'. Together they form a unique fingerprint.

Cite this