Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Giancarlo Pruneri; Maurilio Ponzoni; Andrés J M Ferreri; Nicola Decarli; Moreno Tresoldi; Francesca Raggi; Chiara Baldessari; Massimo Freschi; Luca Baldini; Maria Goldaniga; Antonino Neri; Nadia Carboni; Francesco Bertolini; Giuseppe Viale

doi:10.1046/j.1365-2141.2002.03654.x

Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Giancarlo Pruneri, Maurilio Ponzoni, Andrés J M Ferreri, Nicola Decarli, Moreno Tresoldi, Francesca Raggi, Chiara Baldessari, Massimo Freschi, Luca Baldini, Maria Goldaniga, Antonino Neri, Nadia Carboni, Francesco Bertolini, Giuseppe Viale

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34⁺ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105⁺ MVD. Multivariate analysis confirmed the independent significant association between CD34⁺ MVD and survival (P = 0.001).

Original language	English
Pages (from-to)	817-820
Number of pages	4
Journal	British Journal of Haematology
Volume	118
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.2002.03654.x
Publication status	Published - 2002

Keywords

Angiogenesis
CD105
CD34
Multiple myeloma
Prognosis

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2002.03654.x

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Pruneri, G., Ponzoni, M., Ferreri, A. J. M., Decarli, N., Tresoldi, M., Raggi, F., Baldessari, C., Freschi, M., Baldini, L., Goldaniga, M., Neri, A., Carboni, N., Bertolini, F., & Viale, G. (2002). Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients. British Journal of Haematology, 118(3), 817-820. https://doi.org/10.1046/j.1365-2141.2002.03654.x

Pruneri, G , Ponzoni, M , Ferreri, AJM, Decarli, N, Tresoldi, M, Raggi, F, Baldessari, C, Freschi, M, Baldini, L , Goldaniga, M , Neri, A, Carboni, N, Bertolini, F & Viale, G 2002, 'Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients', British Journal of Haematology, vol. 118, no. 3, pp. 817-820. https://doi.org/10.1046/j.1365-2141.2002.03654.x

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abstract = "We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).",

keywords = "Angiogenesis, CD105, CD34, Multiple myeloma, Prognosis",

author = "Giancarlo Pruneri and Maurilio Ponzoni and Ferreri, {Andr{\'e}s J M} and Nicola Decarli and Moreno Tresoldi and Francesca Raggi and Chiara Baldessari and Massimo Freschi and Luca Baldini and Maria Goldaniga and Antonino Neri and Nadia Carboni and Francesco Bertolini and Giuseppe Viale",

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doi = "10.1046/j.1365-2141.2002.03654.x",

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AU - Pruneri, Giancarlo

AU - Ponzoni, Maurilio

AU - Ferreri, Andrés J M

AU - Decarli, Nicola

AU - Tresoldi, Moreno

AU - Raggi, Francesca

AU - Baldessari, Chiara

AU - Freschi, Massimo

AU - Baldini, Luca

AU - Goldaniga, Maria

AU - Neri, Antonino

AU - Carboni, Nadia

AU - Bertolini, Francesco

AU - Viale, Giuseppe

PY - 2002

Y1 - 2002

N2 - We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).

AB - We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).

KW - Angiogenesis

KW - CD105

KW - CD34

KW - Multiple myeloma

KW - Prognosis

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Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Abstract

Keywords

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