Abstract
We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).
| Original language | English |
|---|---|
| Pages (from-to) | 817-820 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 118 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Angiogenesis
- CD105
- CD34
- Multiple myeloma
- Prognosis
ASJC Scopus subject areas
- Hematology
Cite this
Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients. / Pruneri, Giancarlo; Ponzoni, Maurilio; Ferreri, Andrés J M; Decarli, Nicola; Tresoldi, Moreno; Raggi, Francesca; Baldessari, Chiara; Freschi, Massimo; Baldini, Luca; Goldaniga, Maria; Neri, Antonino; Carboni, Nadia; Bertolini, Francesco; Viale, Giuseppe.
In: British Journal of Haematology, Vol. 118, No. 3, 2002, p. 817-820.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients
AU - Pruneri, Giancarlo
AU - Ponzoni, Maurilio
AU - Ferreri, Andrés J M
AU - Decarli, Nicola
AU - Tresoldi, Moreno
AU - Raggi, Francesca
AU - Baldessari, Chiara
AU - Freschi, Massimo
AU - Baldini, Luca
AU - Goldaniga, Maria
AU - Neri, Antonino
AU - Carboni, Nadia
AU - Bertolini, Francesco
AU - Viale, Giuseppe
PY - 2002
Y1 - 2002
N2 - We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).
AB - We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).
KW - Angiogenesis
KW - CD105
KW - CD34
KW - Multiple myeloma
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=0036037427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036037427&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.2002.03654.x
DO - 10.1046/j.1365-2141.2002.03654.x
M3 - Article
VL - 118
SP - 817
EP - 820
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 3
ER -