Abstract
We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).
Original language | English |
---|---|
Pages (from-to) | 817-820 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 118 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- Angiogenesis
- CD105
- CD34
- Multiple myeloma
- Prognosis
ASJC Scopus subject areas
- Hematology