Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Giancarlo Pruneri; Maurilio Ponzoni; Andrés J M Ferreri; Nicola Decarli; Moreno Tresoldi; Francesca Raggi; Chiara Baldessari; Massimo Freschi; Luca Baldini; Maria Goldaniga; Antonino Neri; Nadia Carboni; Francesco Bertolini; Giuseppe Viale

doi:10.1046/j.1365-2141.2002.03654.x

Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Giancarlo Pruneri, Maurilio Ponzoni, Andrés J M Ferreri, Nicola Decarli, Moreno Tresoldi, Francesca Raggi, Chiara Baldessari, Massimo Freschi, Luca Baldini, Maria Goldaniga, Antonino Neri, Nadia Carboni, Francesco Bertolini, Giuseppe Viale

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34⁺ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105⁺ MVD. Multivariate analysis confirmed the independent significant association between CD34⁺ MVD and survival (P = 0.001).

Original language	English
Pages (from-to)	817-820
Number of pages	4
Journal	British Journal of Haematology
Volume	118
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.2002.03654.x
Publication status	Published - 2002

Keywords

Angiogenesis
CD105
CD34
Multiple myeloma
Prognosis

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2002.03654.x

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Pruneri, G., Ponzoni, M., Ferreri, A. J. M., Decarli, N., Tresoldi, M., Raggi, F., Baldessari, C., Freschi, M., Baldini, L., Goldaniga, M., Neri, A., Carboni, N., Bertolini, F., & Viale, G. (2002). Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients. British Journal of Haematology, 118(3), 817-820. https://doi.org/10.1046/j.1365-2141.2002.03654.x

Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients. / Pruneri, Giancarlo ; Ponzoni, Maurilio ; Ferreri, Andrés J M; Decarli, Nicola; Tresoldi, Moreno; Raggi, Francesca; Baldessari, Chiara; Freschi, Massimo; Baldini, Luca ; Goldaniga, Maria ; Neri, Antonino; Carboni, Nadia; Bertolini, Francesco ; Viale, Giuseppe.

In: British Journal of Haematology, Vol. 118, No. 3, 2002, p. 817-820.

Research output: Contribution to journal › Article › peer-review

Pruneri, G , Ponzoni, M , Ferreri, AJM, Decarli, N, Tresoldi, M, Raggi, F, Baldessari, C, Freschi, M, Baldini, L , Goldaniga, M , Neri, A, Carboni, N, Bertolini, F & Viale, G 2002, 'Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients', British Journal of Haematology, vol. 118, no. 3, pp. 817-820. https://doi.org/10.1046/j.1365-2141.2002.03654.x

Pruneri, Giancarlo ; Ponzoni, Maurilio ; Ferreri, Andrés J M ; Decarli, Nicola ; Tresoldi, Moreno ; Raggi, Francesca ; Baldessari, Chiara ; Freschi, Massimo ; Baldini, Luca ; Goldaniga, Maria ; Neri, Antonino ; Carboni, Nadia ; Bertolini, Francesco ; Viale, Giuseppe. / Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients. In: British Journal of Haematology. 2002 ; Vol. 118, No. 3. pp. 817-820.

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abstract = "We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).",

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AU - Ponzoni, Maurilio

AU - Ferreri, Andrés J M

AU - Decarli, Nicola

AU - Tresoldi, Moreno

AU - Raggi, Francesca

AU - Baldessari, Chiara

AU - Freschi, Massimo

AU - Baldini, Luca

AU - Goldaniga, Maria

AU - Neri, Antonino

AU - Carboni, Nadia

AU - Bertolini, Francesco

AU - Viale, Giuseppe

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N2 - We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).

AB - We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).

KW - Angiogenesis

KW - CD105

KW - CD34

KW - Multiple myeloma

KW - Prognosis

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Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Abstract

Keywords

ASJC Scopus subject areas

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