Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Giancarlo Pruneri, Maurilio Ponzoni, Andrés J M Ferreri, Nicola Decarli, Moreno Tresoldi, Francesca Raggi, Chiara Baldessari, Massimo Freschi, Luca Baldini, Maria Goldaniga, Antonino Neri, Nadia Carboni, Francesco Bertolini, Giuseppe Viale

Research output: Contribution to journalArticle

Abstract

We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).

Original languageEnglish
Pages (from-to)817-820
Number of pages4
JournalBritish Journal of Haematology
Volume118
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Angiogenesis
  • CD105
  • CD34
  • Multiple myeloma
  • Prognosis

ASJC Scopus subject areas

  • Hematology

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