Microvessel quantitation and prognosis in invasive breast carcinoma

Silvano Bosari, Arthur K C Lee, Ronald A. DeLellis, Brian D. Wiley, Gerald J. Heatley, Mark L. Silverman

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Abstract

The prognostic significance of microvessel quantitation in invasive breast carcinoma was analyzed in a study group that comprised 88 patients with axillary node-negative carcinoma and 32 patients with axillary node-positive carcinoma who had a minimum follow-up period of 9 years. Microvessels were identified by immunohistochemistry using antibodies to endothelial markers, including factor VIII-related antigen and blood group isoantigens (ABH). Factor VIII-related antigen staining provided more consistent results for microvessel quantitation than did staining for ABH isoantigens. The three most vascular areas within a tumor were selected, and the microvessels within a ×200 microscopic field of each area were counted by two investigators simultaneously. Node-positive carcinomas demonstrated significantly higher microvessel counts than did node-negative carcinomas (mean ± SD, 99 ± 42 and 73 ± 22, respectively; P <.001). In node-negative carcinomas, tumors from patients who experienced distant recurrence had higher microvessel counts than did tumors from patients who were disease-free (84 ± 19 and 70 ± 22; P = .01). Similarly, in patients with node-positive carcinoma, microvessel counts were considerably higher in tumors from patients who experienced distant recurrence than in patients who did not, although the difference did not reach statistical significance (113 ± 44 and 93 ± 34, respectively). Among patients with node-negative carcinoma, those with a microvessel count of less than 84 had a recurrence rate of 20% compared with 57% in patients with counts greater than 84 (P = .003). Microvessel counts were independent of histologic parameters, ploidy status, and S-phase fraction but correlated with peritumoral vascular invasion. Both microvessel counts and vascular invasion were independent prognostic parameters by multivariate analysis. High vessel counts may represent increased tumor angiogenesis and are correlated with tumor aggressiveness. Microvessel quantitation may be an additional prognostic factor that, when used in conjunction with more established parameters, can help in appropriate patient management.

Original languageEnglish
Pages (from-to)755-761
Number of pages7
JournalHuman Pathology
Volume23
Issue number7
DOIs
Publication statusPublished - 1992

Fingerprint

Microvessels
Breast Neoplasms
Carcinoma
Blood Vessels
Neoplasms
Isoantigens
von Willebrand Factor
Recurrence
ABO Blood-Group System
Staining and Labeling
Ploidies
S Phase
Multivariate Analysis
Immunohistochemistry
Research Personnel
Antibodies

Keywords

  • angiogenesis
  • breast carcinoma
  • immunohistochemistry
  • microvessel counts
  • prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Bosari, S., Lee, A. K. C., DeLellis, R. A., Wiley, B. D., Heatley, G. J., & Silverman, M. L. (1992). Microvessel quantitation and prognosis in invasive breast carcinoma. Human Pathology, 23(7), 755-761. https://doi.org/10.1016/0046-8177(92)90344-3

Microvessel quantitation and prognosis in invasive breast carcinoma. / Bosari, Silvano; Lee, Arthur K C; DeLellis, Ronald A.; Wiley, Brian D.; Heatley, Gerald J.; Silverman, Mark L.

In: Human Pathology, Vol. 23, No. 7, 1992, p. 755-761.

Research output: Contribution to journalArticle

Bosari, S, Lee, AKC, DeLellis, RA, Wiley, BD, Heatley, GJ & Silverman, ML 1992, 'Microvessel quantitation and prognosis in invasive breast carcinoma', Human Pathology, vol. 23, no. 7, pp. 755-761. https://doi.org/10.1016/0046-8177(92)90344-3
Bosari, Silvano ; Lee, Arthur K C ; DeLellis, Ronald A. ; Wiley, Brian D. ; Heatley, Gerald J. ; Silverman, Mark L. / Microvessel quantitation and prognosis in invasive breast carcinoma. In: Human Pathology. 1992 ; Vol. 23, No. 7. pp. 755-761.
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