Abstract
Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl)prop- 2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4- methoxybenzenesulfonamide, a well-known Ca2+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are described. The methods proposed start from easily available reagents- and allow ready preparation of the final compound in moderate- overall yields. Most of the synthetic steps proposed were microwave assisted.
Original language | English |
---|---|
Article number | T14310SS |
Pages (from-to) | 4193-4198 |
Number of pages | 6 |
Journal | Synthesis |
Issue number | 24 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- enzymes
- Heck reaction
- medicinal chemistry
- multicomponent reaction
- sulfonamides
ASJC Scopus subject areas
- Organic Chemistry
- Catalysis