Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II

Claudio Bruno, Giovanni Lentini, Alessia Catalano, Alessia Carocci, Angelo Lovece, Antonia Di Mola, Maria Maddalena Cavalluzzi, Paolo Tortorella, Fulvio Loiodice, Guido Iaccarino, Pietro Campiglia, Ettore Novellino, Carlo Franchini

Research output: Contribution to journalArticlepeer-review

Abstract

Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl)prop- 2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4- methoxybenzenesulfonamide, a well-known Ca2+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are described. The methods proposed start from easily available reagents- and allow ready preparation of the final compound in moderate- overall yields. Most of the synthetic steps proposed were microwave assisted.

Original languageEnglish
Article numberT14310SS
Pages (from-to)4193-4198
Number of pages6
JournalSynthesis
Issue number24
DOIs
Publication statusPublished - 2010

Keywords

  • enzymes
  • Heck reaction
  • medicinal chemistry
  • multicomponent reaction
  • sulfonamides

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

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