Mid-term evaluation of the effects of dynamic neutralization system on lumbar intervertebral discs using quantitative molecular MR imaging

Cristina Ciavarro, Enrico G. Caiani, Marco Brayda-Bruno, Alberto Zerbi, Fabio Galbusera, Stefania Vaga, Claudio Lamartina

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To evaluate the mid-term effects of implant of dynamic neutralization system (Dynesys) on disc tissue in patients with lumbar discopathy, through the quantification of glycosaminoglycans (GAG) concentration, both in treated and adjacent levels, by analysis of delayed gadolinium-enhanced MRI contrast (dGEMRIC) images. Materials and Methods: Ten patients with low back pain underwent the dGEMRIC diagnostic protocol before, 6-months and after 2 years from surgery. Each patient was also evaluated with visual analog (VAS), Oswestry, and Prolo scales both at presurgery and during follow-up. From dGEMRIC images, a ΔT1 parametric map was obtained for each disc, as quantitative indicator of its GAG concentration, and divided in 13 sectors, which were classified at presurgery as normal or abnormal, based on a 70-ms threshold. Evolution of ΔT1 was studied during the follow-up. Results: Nine of ten patients completed the follow-up. VAS, Oswestry, and Prolo grades showed an improvement. This was accompanied by a reduction of ΔT1 in abnormal segments while normal segments showed a pattern of initial worsening at 6 months, followed by an improvement after 2 years. Conclusion: Our study confirmed the improvement in clinical evaluation, and for the first time related this to the changes in discs GAG concentration.

Original languageEnglish
Pages (from-to)1145-1151
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume35
Issue number5
DOIs
Publication statusPublished - May 2012

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Molecular Imaging
Intervertebral Disc
Gadolinium
Glycosaminoglycans
Low Back Pain

Keywords

  • dGEMRIC
  • Dynamic neutralization system
  • Image processing
  • Lumbar spine
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Mid-term evaluation of the effects of dynamic neutralization system on lumbar intervertebral discs using quantitative molecular MR imaging. / Ciavarro, Cristina; Caiani, Enrico G.; Brayda-Bruno, Marco; Zerbi, Alberto; Galbusera, Fabio; Vaga, Stefania; Lamartina, Claudio.

In: Journal of Magnetic Resonance Imaging, Vol. 35, No. 5, 05.2012, p. 1145-1151.

Research output: Contribution to journalArticle

Ciavarro, Cristina ; Caiani, Enrico G. ; Brayda-Bruno, Marco ; Zerbi, Alberto ; Galbusera, Fabio ; Vaga, Stefania ; Lamartina, Claudio. / Mid-term evaluation of the effects of dynamic neutralization system on lumbar intervertebral discs using quantitative molecular MR imaging. In: Journal of Magnetic Resonance Imaging. 2012 ; Vol. 35, No. 5. pp. 1145-1151.
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