Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results

F. D'Ascenzo, F. Conrotto, F. Giordana, C. Moretti, M. D'Amico, S. Salizzoni, P. Omedè, M. La Torre, M. Thomas, Z. Khawaja, D. Hildick-Smith, Gp Ussia, M. Barbanti, C. Tamburino, John Webb, R. B. Schnabel, M. Seiffert, S. Wilde, H. Treede, V. GasparettoM. Napodano, G. Tarantini, P. Presbitero, M. Mennuni, M. L. Rossi, M. Gasparini, G. Biondi Zoccai, M. Lupo, M. Rinaldi, F. Gaita, S. Marra

Research output: Contribution to journalArticle

Abstract

Aims Coronary artery disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, being currently evaluated in the most common used risk score. Our meta-analysis aims to clarify the prognostic role of CAD on mid-term survival in patients undergoing TAVI. Methods and results Studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI were systematically searched for and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 52%(42-65) of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14-32) for cardiovascular death. At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, confidence interval, 0.67-1.50 I2 0%). Conclusion CAD does not affect mid-term TAVI outcome: this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.

Original languageEnglish
Pages (from-to)2528-2532
Number of pages5
JournalInternational Journal of Cardiology
Volume168
Issue number3
DOIs
Publication statusPublished - Oct 3 2013

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Keywords

  • CAD
  • Mid-term outcomes
  • TAVI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

D'Ascenzo, F., Conrotto, F., Giordana, F., Moretti, C., D'Amico, M., Salizzoni, S., Omedè, P., La Torre, M., Thomas, M., Khawaja, Z., Hildick-Smith, D., Ussia, G., Barbanti, M., Tamburino, C., Webb, J., Schnabel, R. B., Seiffert, M., Wilde, S., Treede, H., ... Marra, S. (2013). Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis of adjusted observational results. International Journal of Cardiology, 168(3), 2528-2532. https://doi.org/10.1016/j.ijcard.2013.03.062