Midlatency auditory event-related potentials in mice

Comparison to midlatency auditory ERPs in humans

Daniel Umbricht, Dimitri Vyssotky, Alexander Latanov, Roger Nitsch, Riccardo Brambilla, Patrizia D'Adamo, Hans Peter Lipp

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Midlatency event-related potentials (ERPs) reflect early stages in processing of modality specific information. In humans, the auditory midlatency ERPs most investigated are the P1, N1 and P2. Abnormalities of these ERPs in neuropsychiatric disorders such as schizophrenia point to deficits in information processing at early stages. Investigations of corresponding ERPs in mice might thus permit to elucidate the molecular biology of such abnormalities. We conducted studies in mice and humans in order to establish the correspondence of midlatency ERPs in mice to the human P1, N1 and P2. We investigated their so-called recovery function - i.e. their systematic amplitude changes as a function of varying stimulus onset asynchrony (SOA). Furthermore, we explored effects of specific genetic alterations (ERK1 gene deletion Gdi1 gene deletion) on this measure. In mice, P1-like activity showed a significant recovery not present in human data. In contrast, N1-like and P2-like activity in mice demonstrated similar recovery functions as the corresponding ERPs in human subjects and could be best fitted by the same function. In addition, ERK1 gene knockout mice showed a significantly different N1 recovery function compared to wild-type mice, possibly related to enhanced memory functions in these mice. Our results indicate that midlatency ERPs in mice share some, but not all, characteristics with the human P1, N1 and P2. As in humans, N1 recovery may provide an assessment of auditory sensory memory function. Investigations of these ERPs in mice may thus permit to elucidate the abnormalities underlying deficient generation of these ERPs in neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)189-200
Number of pages12
JournalBrain Research
Volume1019
Issue number1-2
DOIs
Publication statusPublished - Sep 3 2004

Fingerprint

Evoked Potentials
Recovery of Function
Gene Deletion
Gene Knockout Techniques
Automatic Data Processing
Knockout Mice
Molecular Biology
Schizophrenia

Keywords

  • Auditory systems
  • Central physiology
  • ERK1 gene KO mouse
  • Event-related potential
  • Gdi1 gene KO mouse
  • N1
  • P1
  • P2
  • Sensory systems

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Midlatency auditory event-related potentials in mice : Comparison to midlatency auditory ERPs in humans. / Umbricht, Daniel; Vyssotky, Dimitri; Latanov, Alexander; Nitsch, Roger; Brambilla, Riccardo; D'Adamo, Patrizia; Lipp, Hans Peter.

In: Brain Research, Vol. 1019, No. 1-2, 03.09.2004, p. 189-200.

Research output: Contribution to journalArticle

Umbricht, D, Vyssotky, D, Latanov, A, Nitsch, R, Brambilla, R, D'Adamo, P & Lipp, HP 2004, 'Midlatency auditory event-related potentials in mice: Comparison to midlatency auditory ERPs in humans', Brain Research, vol. 1019, no. 1-2, pp. 189-200. https://doi.org/10.1016/j.brainres.2004.05.097
Umbricht, Daniel ; Vyssotky, Dimitri ; Latanov, Alexander ; Nitsch, Roger ; Brambilla, Riccardo ; D'Adamo, Patrizia ; Lipp, Hans Peter. / Midlatency auditory event-related potentials in mice : Comparison to midlatency auditory ERPs in humans. In: Brain Research. 2004 ; Vol. 1019, No. 1-2. pp. 189-200.
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