Midregional proadrenomedullin (MR-proADM) is a powerful predictor of early death in AL amyloidosis

Giovanni Palladini, Alessandra Barassi, Stefano Perlini, Paolo Milani, Andrea Foli, Paola Russo, Riccardo Albertini, Laura Obici, Francesca Lavatelli, Gabriele Sarais, Simona Casarini, Remigio Moratti, Gian Vico Melzi D'Eril, Giampaolo Merlini

Research output: Contribution to journalArticle

Abstract

Background: Cardiac biomarkers play a major role in the identification of patients at risk of early death in AL amyloidosis, and a staging system based on amino-terminal pro-natriuretic peptide type-B (NT-proBNP) and troponins (cTn) is used for prognostic stratification. Adrenomedullin is produced by several tissues including the heart, and portends a poor prognosis in heart diseases. We investigated the ability of midregional proadrenomedullin (MR-proADM) to predict early death in AL amyloidosis. Methods: One-hundred and thirty consecutive patients with newly-diagnosed AL amyloidosis were prospectively enrolled. The impact on survival of NT-proBNP, cTnI and MR-proADM was evaluated. Results: The concentration of MR-proADM correlated with systolic and diastolic function, but did not reflect the amount of amyloid deposited in the heart. Moreover, MR-proADM was associated with non-cardiac markers of advanced disease. The staging system based on NT-proBNP and cTnI identified high-risk subjects, but could not discriminate good-risk and intermediate-risk patients. Conversely, a staging system based on MR-proADM and cTnI identified 3 groups with significantly different survivals. Conclusions: Midregional-proADM is a powerful prognostic marker in AL amyloidosis, which may not only reflect cardiac dysfunction but also widespread systemic disease, and can be combined with cTn for detecting patients at risk of early death.

Original languageEnglish
Pages (from-to)216-221
Number of pages6
JournalAmyloid
Volume18
Issue number4
DOIs
Publication statusPublished - Dec 2011

Keywords

  • B-type natriuretic peptide
  • Heart
  • Prognosis
  • Staging
  • Survival
  • Troponin

ASJC Scopus subject areas

  • Internal Medicine

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