Midwall mechanics are improved after regression of hypertensive left ventricular hypertrophy and normalization of chamber geometry

Stefano Perlini, Maria Lorenza Muiesan, Cesare Cuspidi, Lorena Sampieri, Bruno Trimarco, Gerard P. Aurigemma, Enrico Agabiti-Rosei, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

Background - It is still unclear whether substantial regression of hypertensive left ventricular hypertrophy (LVH) and normalization of chamber geometry are associated with improved left ventricular (LV) myocardial function. Methods and Results - Midwall mechanics were evaluated in 152 patients undergoing 1 year of effective antihypertensive treatment. Two-dimensionally directed M-mode echocardiography was performed as follows: (1) after a 4-week placebo "run-in" period, (2) after 1 year of treatment with 20 mg/d lisinopril (alone or associated with 12.5 to 25 mg/d hydrochlorothiazide), and (3) after a final 1-month placebo period to allow blood pressure (24-hour average ambulatory monitoring) to return to pretreatment levels. Treatment-induced reductions in blood pressure (from 149±16/95±11 to 131±12/83±10 mm Hg, P2, P±0.05) were associated with a marked reduction in LV mass index (from 159±30 to 133±26 g/m2, P

Original languageEnglish
Pages (from-to)678-683
Number of pages6
JournalCirculation
Volume103
Issue number5
Publication statusPublished - Feb 6 2001

Keywords

  • Echocardiography
  • Hemodynamics
  • Hypertrophy
  • Myocardial contraction
  • Systole

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Midwall mechanics are improved after regression of hypertensive left ventricular hypertrophy and normalization of chamber geometry'. Together they form a unique fingerprint.

Cite this