Mig-14 is a horizontally acquired, host-induced gene required for Salmonella enterica lethal infection in the murine model of typhoid fever

Raphael H. Valdivia, Daniela M. Cirillo, Anthea K. Lee, Donna M. Bouley, Stanley Falkow

Research output: Contribution to journalArticle

Abstract

We have characterized a host-induced virulence gene, mig-14, that is required for fatal infection in the mouse model of enteric fever, mig-14 is present in all Salmonella enterica subspecies I serovars and maps to a region of the chromosome that appears to have been acquired by horizontal transmission. A mig-14 mutant replicated in host tissues early after infection but was later cleared from the spleens and livers of infected animals, Bacterial clearance by the host occurred concomitantly with an increase in gamma interferon levels and recruitment of macrophages, but few neutrophils, to the infection foci. We hypothesize that the mig-14 gene product may repress immune system functions by interfering with normal cytokine expression in response to bacterial infections.

Original languageEnglish
Pages (from-to)7126-7131
Number of pages6
JournalInfection and Immunity
Volume68
Issue number12
DOIs
Publication statusPublished - 2000

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Salmonella enterica
Typhoid Fever
Infection
Genes
Bacterial Infections
Interferon-gamma
Virulence
Immune System
Neutrophils
Spleen
Chromosomes
Macrophages
Cytokines
Liver

ASJC Scopus subject areas

  • Immunology

Cite this

Mig-14 is a horizontally acquired, host-induced gene required for Salmonella enterica lethal infection in the murine model of typhoid fever. / Valdivia, Raphael H.; Cirillo, Daniela M.; Lee, Anthea K.; Bouley, Donna M.; Falkow, Stanley.

In: Infection and Immunity, Vol. 68, No. 12, 2000, p. 7126-7131.

Research output: Contribution to journalArticle

Valdivia, Raphael H. ; Cirillo, Daniela M. ; Lee, Anthea K. ; Bouley, Donna M. ; Falkow, Stanley. / Mig-14 is a horizontally acquired, host-induced gene required for Salmonella enterica lethal infection in the murine model of typhoid fever. In: Infection and Immunity. 2000 ; Vol. 68, No. 12. pp. 7126-7131.
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