Migraine headache and mood disorders: A descriptive study in an outpatient psychiatric population

Linda Franchini, Fanny Bongiorno, Danilo Dotoli, Innocenzo Rainero, Lorenzo Pinessi, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


Background: Information is sparse concerning migraine distribution in mood disorder subjects based mainly on psychiatric disorder. Methods: In a sample of 283 normothymic mood disorder outpatients on maintenance treatment with serotonin reuptake inhibitors (SSRIs) or lithium, we investigated migraine distribution and clinical variables possibly related to comorbidity risk between mood disorder and migraine. Results: Some 26.8% of the sample met criteria for migraine with migraine age of onset earlier than mood disorder age of onset; familiarity for mood disorder and migraine was strictly related to comorbidity risk in probands. Long-term treatment with lithium salts subjectively improved migraine outcome. Conclusions: These results could support the bidirectional association between the two clinical forms, considering the familial and pharmacological patterns.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalJournal of Affective Disorders
Issue number2
Publication statusPublished - Aug 2004


  • Familiarity
  • Migraine
  • Mood disorder
  • Normothymia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)


Dive into the research topics of 'Migraine headache and mood disorders: A descriptive study in an outpatient psychiatric population'. Together they form a unique fingerprint.

Cite this