Migraine improvement after spontaneous cervical artery dissection the Italian Project on Stroke in Young Adults (IPSYS)

on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators

Research output: Contribution to journalArticle

Abstract

Objective: Whether migraine modifies after spontaneous cervical artery dissection (sCeAD) more than after other stroke etiologic subtypes has never been adequately investigated. Methods: In the setting of the Italian Project on Stroke in Young Adults (IPSYS), we compared the course of migraine before and after acute brain infarct in a group of migraine patients with sCeAD and a group of migraine patients whose ischemia was due to a cause other than CeAD (non-CeAD IS), matched by sex, age (± 3 years), and migraine subtype.We applied linear mixed models to evaluate pre-event vs post-event changes and differences between sCeAD and non-CeAD IS patients. Results: Eighty-seven patients per group (migraine without aura/migraine with aura, 67/20) qualified for the analysis. After the acute event, migraine headaches disappeared in 14.0% of CeAD patients vs 0.0% of non-CeAD IS patients (p ≤ 0.001). Migraine frequency (patients suffering at least 1 attack, from 93.1 to 80.5%, p = 0.001), pain intensity (from 6.7 ± 1.7 to 4.6 ± 2.6 in a 0 to 10 pain scale, p ≤ 0.001), and use of acute anti-migraine medications (patients taking at least 1 preparation, from 81.6 to 64.4%, p = 0.007) also improved significantly after CeAD as opposed to that observed after non-CeAD IS. Conclusion: The spontaneous improvement of migraine after sCeAD reinforces the hypothesis of a pathogenic link between the two conditions.

Original languageEnglish
JournalNeurological Sciences
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Migraine Disorders
Dissection
Young Adult
Arteries
Stroke
Migraine without Aura
Migraine with Aura
Pain
Linear Models
Ischemia
Brain

Keywords

  • Cervical artery dissection
  • Migraine
  • Stroke in young adults

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Migraine improvement after spontaneous cervical artery dissection the Italian Project on Stroke in Young Adults (IPSYS). / on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators.

In: Neurological Sciences, 01.01.2018.

Research output: Contribution to journalArticle

on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators. / Migraine improvement after spontaneous cervical artery dissection the Italian Project on Stroke in Young Adults (IPSYS). In: Neurological Sciences. 2018.
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title = "Migraine improvement after spontaneous cervical artery dissection the Italian Project on Stroke in Young Adults (IPSYS)",
abstract = "Objective: Whether migraine modifies after spontaneous cervical artery dissection (sCeAD) more than after other stroke etiologic subtypes has never been adequately investigated. Methods: In the setting of the Italian Project on Stroke in Young Adults (IPSYS), we compared the course of migraine before and after acute brain infarct in a group of migraine patients with sCeAD and a group of migraine patients whose ischemia was due to a cause other than CeAD (non-CeAD IS), matched by sex, age (± 3 years), and migraine subtype.We applied linear mixed models to evaluate pre-event vs post-event changes and differences between sCeAD and non-CeAD IS patients. Results: Eighty-seven patients per group (migraine without aura/migraine with aura, 67/20) qualified for the analysis. After the acute event, migraine headaches disappeared in 14.0{\%} of CeAD patients vs 0.0{\%} of non-CeAD IS patients (p ≤ 0.001). Migraine frequency (patients suffering at least 1 attack, from 93.1 to 80.5{\%}, p = 0.001), pain intensity (from 6.7 ± 1.7 to 4.6 ± 2.6 in a 0 to 10 pain scale, p ≤ 0.001), and use of acute anti-migraine medications (patients taking at least 1 preparation, from 81.6 to 64.4{\%}, p = 0.007) also improved significantly after CeAD as opposed to that observed after non-CeAD IS. Conclusion: The spontaneous improvement of migraine after sCeAD reinforces the hypothesis of a pathogenic link between the two conditions.",
keywords = "Cervical artery dissection, Migraine, Stroke in young adults",
author = "{on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators} and {De Giuli}, Valeria and Francesca Graziano and Andrea Zini and Marialuisa Zedde and Rosalba Patella and Corrado Lodigiani and Simona Marcheselli and DeLodovici, {Maria Luisa} and Maurizio Paciaroni and Ilaria Casetta and Elisa Giorli and Alessandro Adami and Massimiliano Braga and Carmela Casella and Alessia Giossi and Giorgio Silvestrelli and Lucia Tancredi and Lotti, {Enrico Maria} and Loris Poli and Filomena Caria and Valeria Piras and Laura Cucurachi and Massimo Gamba and Mario Grassi and Alessandro Padovani and Alessandro Pezzini",
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AU - on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators

AU - De Giuli, Valeria

AU - Graziano, Francesca

AU - Zini, Andrea

AU - Zedde, Marialuisa

AU - Patella, Rosalba

AU - Lodigiani, Corrado

AU - Marcheselli, Simona

AU - DeLodovici, Maria Luisa

AU - Paciaroni, Maurizio

AU - Casetta, Ilaria

AU - Giorli, Elisa

AU - Adami, Alessandro

AU - Braga, Massimiliano

AU - Casella, Carmela

AU - Giossi, Alessia

AU - Silvestrelli, Giorgio

AU - Tancredi, Lucia

AU - Lotti, Enrico Maria

AU - Poli, Loris

AU - Caria, Filomena

AU - Piras, Valeria

AU - Cucurachi, Laura

AU - Gamba, Massimo

AU - Grassi, Mario

AU - Padovani, Alessandro

AU - Pezzini, Alessandro

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: Whether migraine modifies after spontaneous cervical artery dissection (sCeAD) more than after other stroke etiologic subtypes has never been adequately investigated. Methods: In the setting of the Italian Project on Stroke in Young Adults (IPSYS), we compared the course of migraine before and after acute brain infarct in a group of migraine patients with sCeAD and a group of migraine patients whose ischemia was due to a cause other than CeAD (non-CeAD IS), matched by sex, age (± 3 years), and migraine subtype.We applied linear mixed models to evaluate pre-event vs post-event changes and differences between sCeAD and non-CeAD IS patients. Results: Eighty-seven patients per group (migraine without aura/migraine with aura, 67/20) qualified for the analysis. After the acute event, migraine headaches disappeared in 14.0% of CeAD patients vs 0.0% of non-CeAD IS patients (p ≤ 0.001). Migraine frequency (patients suffering at least 1 attack, from 93.1 to 80.5%, p = 0.001), pain intensity (from 6.7 ± 1.7 to 4.6 ± 2.6 in a 0 to 10 pain scale, p ≤ 0.001), and use of acute anti-migraine medications (patients taking at least 1 preparation, from 81.6 to 64.4%, p = 0.007) also improved significantly after CeAD as opposed to that observed after non-CeAD IS. Conclusion: The spontaneous improvement of migraine after sCeAD reinforces the hypothesis of a pathogenic link between the two conditions.

AB - Objective: Whether migraine modifies after spontaneous cervical artery dissection (sCeAD) more than after other stroke etiologic subtypes has never been adequately investigated. Methods: In the setting of the Italian Project on Stroke in Young Adults (IPSYS), we compared the course of migraine before and after acute brain infarct in a group of migraine patients with sCeAD and a group of migraine patients whose ischemia was due to a cause other than CeAD (non-CeAD IS), matched by sex, age (± 3 years), and migraine subtype.We applied linear mixed models to evaluate pre-event vs post-event changes and differences between sCeAD and non-CeAD IS patients. Results: Eighty-seven patients per group (migraine without aura/migraine with aura, 67/20) qualified for the analysis. After the acute event, migraine headaches disappeared in 14.0% of CeAD patients vs 0.0% of non-CeAD IS patients (p ≤ 0.001). Migraine frequency (patients suffering at least 1 attack, from 93.1 to 80.5%, p = 0.001), pain intensity (from 6.7 ± 1.7 to 4.6 ± 2.6 in a 0 to 10 pain scale, p ≤ 0.001), and use of acute anti-migraine medications (patients taking at least 1 preparation, from 81.6 to 64.4%, p = 0.007) also improved significantly after CeAD as opposed to that observed after non-CeAD IS. Conclusion: The spontaneous improvement of migraine after sCeAD reinforces the hypothesis of a pathogenic link between the two conditions.

KW - Cervical artery dissection

KW - Migraine

KW - Stroke in young adults

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