Migraine is a risk factor for hypertensive disorders in pregnancy: A prospective cohort study

F. Facchinetti, G. Allais, R. E. Nappi, R. D'Amico, L. Marozio, L. Bertozzi, A. Ornati, C. Benedetto

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The aim was to assess whether women suffering from migraine are at higher risk of developing hypertensive disorders in pregnancy. In a prospective cohort study, performed at antenatal clinics in three maternity units in Northern Italy, 702 normotensive women with singleton pregnancy at 11-16 weeks' gestation were enrolled. Women with a history of hypertensive disorders in pregnancy or presenting chronic hypertension were excluded. The presence of migraine was investigated according to International Headache Society criteria. The main outcome measure was the onset of hypertension in pregnancy, defined as the occurrence of either gestational hypertension or preeclampsia. Two hundred and seventy women (38.5%) were diagnosed with migraine. The majority (68.1%) suffered from migraine without aura. The risk of developing hypertensive disorders in pregnancy was higher in migraineurs (9.1%) compared with non-migraineurs (3.1%) [odds ratio (OR) adjusted for age, family history of hypertension and smoking 2.85, 95% confidence interval (CI) 1.40, 5.81]. Women with migraine also showed a trend to increased risk for low birth weight infants with respect to women without migraine (OR 1.97, 95% CI 0.98, 3.98). Women with migraine are to be considered at increased risk of developing hypertensive disorders in pregnancy. The diagnosis of primary headaches should be taken into account at antenatal examination.

Original languageEnglish
Pages (from-to)286-292
Number of pages7
JournalCephalalgia
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Migraine Disorders
Cohort Studies
Prospective Studies
Pregnancy
Hypertension
Headache
Odds Ratio
Confidence Intervals
Migraine without Aura
Pregnancy Induced Hypertension
Low Birth Weight Infant
Pre-Eclampsia
Italy
Smoking
Outcome Assessment (Health Care)

Keywords

  • Antenatal testing
  • Gestational hypertension
  • Migraine
  • Preeclampsia

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Facchinetti, F., Allais, G., Nappi, R. E., D'Amico, R., Marozio, L., Bertozzi, L., ... Benedetto, C. (2009). Migraine is a risk factor for hypertensive disorders in pregnancy: A prospective cohort study. Cephalalgia, 29(3), 286-292. https://doi.org/10.1111/j.1468-2982.2008.01704.x

Migraine is a risk factor for hypertensive disorders in pregnancy : A prospective cohort study. / Facchinetti, F.; Allais, G.; Nappi, R. E.; D'Amico, R.; Marozio, L.; Bertozzi, L.; Ornati, A.; Benedetto, C.

In: Cephalalgia, Vol. 29, No. 3, 03.2009, p. 286-292.

Research output: Contribution to journalArticle

Facchinetti, F, Allais, G, Nappi, RE, D'Amico, R, Marozio, L, Bertozzi, L, Ornati, A & Benedetto, C 2009, 'Migraine is a risk factor for hypertensive disorders in pregnancy: A prospective cohort study', Cephalalgia, vol. 29, no. 3, pp. 286-292. https://doi.org/10.1111/j.1468-2982.2008.01704.x
Facchinetti, F. ; Allais, G. ; Nappi, R. E. ; D'Amico, R. ; Marozio, L. ; Bertozzi, L. ; Ornati, A. ; Benedetto, C. / Migraine is a risk factor for hypertensive disorders in pregnancy : A prospective cohort study. In: Cephalalgia. 2009 ; Vol. 29, No. 3. pp. 286-292.
@article{202a4f1e33d84978971c8cdabc8f7d0e,
title = "Migraine is a risk factor for hypertensive disorders in pregnancy: A prospective cohort study",
abstract = "The aim was to assess whether women suffering from migraine are at higher risk of developing hypertensive disorders in pregnancy. In a prospective cohort study, performed at antenatal clinics in three maternity units in Northern Italy, 702 normotensive women with singleton pregnancy at 11-16 weeks' gestation were enrolled. Women with a history of hypertensive disorders in pregnancy or presenting chronic hypertension were excluded. The presence of migraine was investigated according to International Headache Society criteria. The main outcome measure was the onset of hypertension in pregnancy, defined as the occurrence of either gestational hypertension or preeclampsia. Two hundred and seventy women (38.5{\%}) were diagnosed with migraine. The majority (68.1{\%}) suffered from migraine without aura. The risk of developing hypertensive disorders in pregnancy was higher in migraineurs (9.1{\%}) compared with non-migraineurs (3.1{\%}) [odds ratio (OR) adjusted for age, family history of hypertension and smoking 2.85, 95{\%} confidence interval (CI) 1.40, 5.81]. Women with migraine also showed a trend to increased risk for low birth weight infants with respect to women without migraine (OR 1.97, 95{\%} CI 0.98, 3.98). Women with migraine are to be considered at increased risk of developing hypertensive disorders in pregnancy. The diagnosis of primary headaches should be taken into account at antenatal examination.",
keywords = "Antenatal testing, Gestational hypertension, Migraine, Preeclampsia",
author = "F. Facchinetti and G. Allais and Nappi, {R. E.} and R. D'Amico and L. Marozio and L. Bertozzi and A. Ornati and C. Benedetto",
year = "2009",
month = "3",
doi = "10.1111/j.1468-2982.2008.01704.x",
language = "English",
volume = "29",
pages = "286--292",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Migraine is a risk factor for hypertensive disorders in pregnancy

T2 - A prospective cohort study

AU - Facchinetti, F.

AU - Allais, G.

AU - Nappi, R. E.

AU - D'Amico, R.

AU - Marozio, L.

AU - Bertozzi, L.

AU - Ornati, A.

AU - Benedetto, C.

PY - 2009/3

Y1 - 2009/3

N2 - The aim was to assess whether women suffering from migraine are at higher risk of developing hypertensive disorders in pregnancy. In a prospective cohort study, performed at antenatal clinics in three maternity units in Northern Italy, 702 normotensive women with singleton pregnancy at 11-16 weeks' gestation were enrolled. Women with a history of hypertensive disorders in pregnancy or presenting chronic hypertension were excluded. The presence of migraine was investigated according to International Headache Society criteria. The main outcome measure was the onset of hypertension in pregnancy, defined as the occurrence of either gestational hypertension or preeclampsia. Two hundred and seventy women (38.5%) were diagnosed with migraine. The majority (68.1%) suffered from migraine without aura. The risk of developing hypertensive disorders in pregnancy was higher in migraineurs (9.1%) compared with non-migraineurs (3.1%) [odds ratio (OR) adjusted for age, family history of hypertension and smoking 2.85, 95% confidence interval (CI) 1.40, 5.81]. Women with migraine also showed a trend to increased risk for low birth weight infants with respect to women without migraine (OR 1.97, 95% CI 0.98, 3.98). Women with migraine are to be considered at increased risk of developing hypertensive disorders in pregnancy. The diagnosis of primary headaches should be taken into account at antenatal examination.

AB - The aim was to assess whether women suffering from migraine are at higher risk of developing hypertensive disorders in pregnancy. In a prospective cohort study, performed at antenatal clinics in three maternity units in Northern Italy, 702 normotensive women with singleton pregnancy at 11-16 weeks' gestation were enrolled. Women with a history of hypertensive disorders in pregnancy or presenting chronic hypertension were excluded. The presence of migraine was investigated according to International Headache Society criteria. The main outcome measure was the onset of hypertension in pregnancy, defined as the occurrence of either gestational hypertension or preeclampsia. Two hundred and seventy women (38.5%) were diagnosed with migraine. The majority (68.1%) suffered from migraine without aura. The risk of developing hypertensive disorders in pregnancy was higher in migraineurs (9.1%) compared with non-migraineurs (3.1%) [odds ratio (OR) adjusted for age, family history of hypertension and smoking 2.85, 95% confidence interval (CI) 1.40, 5.81]. Women with migraine also showed a trend to increased risk for low birth weight infants with respect to women without migraine (OR 1.97, 95% CI 0.98, 3.98). Women with migraine are to be considered at increased risk of developing hypertensive disorders in pregnancy. The diagnosis of primary headaches should be taken into account at antenatal examination.

KW - Antenatal testing

KW - Gestational hypertension

KW - Migraine

KW - Preeclampsia

UR - http://www.scopus.com/inward/record.url?scp=59149100783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59149100783&partnerID=8YFLogxK

U2 - 10.1111/j.1468-2982.2008.01704.x

DO - 10.1111/j.1468-2982.2008.01704.x

M3 - Article

C2 - 19220309

AN - SCOPUS:59149100783

VL - 29

SP - 286

EP - 292

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 3

ER -