TY - JOUR
T1 - Migraine is a risk factor for hypertensive disorders in pregnancy
T2 - A prospective cohort study
AU - Facchinetti, F.
AU - Allais, G.
AU - Nappi, R. E.
AU - D'Amico, R.
AU - Marozio, L.
AU - Bertozzi, L.
AU - Ornati, A.
AU - Benedetto, C.
PY - 2009/3
Y1 - 2009/3
N2 - The aim was to assess whether women suffering from migraine are at higher risk of developing hypertensive disorders in pregnancy. In a prospective cohort study, performed at antenatal clinics in three maternity units in Northern Italy, 702 normotensive women with singleton pregnancy at 11-16 weeks' gestation were enrolled. Women with a history of hypertensive disorders in pregnancy or presenting chronic hypertension were excluded. The presence of migraine was investigated according to International Headache Society criteria. The main outcome measure was the onset of hypertension in pregnancy, defined as the occurrence of either gestational hypertension or preeclampsia. Two hundred and seventy women (38.5%) were diagnosed with migraine. The majority (68.1%) suffered from migraine without aura. The risk of developing hypertensive disorders in pregnancy was higher in migraineurs (9.1%) compared with non-migraineurs (3.1%) [odds ratio (OR) adjusted for age, family history of hypertension and smoking 2.85, 95% confidence interval (CI) 1.40, 5.81]. Women with migraine also showed a trend to increased risk for low birth weight infants with respect to women without migraine (OR 1.97, 95% CI 0.98, 3.98). Women with migraine are to be considered at increased risk of developing hypertensive disorders in pregnancy. The diagnosis of primary headaches should be taken into account at antenatal examination.
AB - The aim was to assess whether women suffering from migraine are at higher risk of developing hypertensive disorders in pregnancy. In a prospective cohort study, performed at antenatal clinics in three maternity units in Northern Italy, 702 normotensive women with singleton pregnancy at 11-16 weeks' gestation were enrolled. Women with a history of hypertensive disorders in pregnancy or presenting chronic hypertension were excluded. The presence of migraine was investigated according to International Headache Society criteria. The main outcome measure was the onset of hypertension in pregnancy, defined as the occurrence of either gestational hypertension or preeclampsia. Two hundred and seventy women (38.5%) were diagnosed with migraine. The majority (68.1%) suffered from migraine without aura. The risk of developing hypertensive disorders in pregnancy was higher in migraineurs (9.1%) compared with non-migraineurs (3.1%) [odds ratio (OR) adjusted for age, family history of hypertension and smoking 2.85, 95% confidence interval (CI) 1.40, 5.81]. Women with migraine also showed a trend to increased risk for low birth weight infants with respect to women without migraine (OR 1.97, 95% CI 0.98, 3.98). Women with migraine are to be considered at increased risk of developing hypertensive disorders in pregnancy. The diagnosis of primary headaches should be taken into account at antenatal examination.
KW - Antenatal testing
KW - Gestational hypertension
KW - Migraine
KW - Preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=59149100783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59149100783&partnerID=8YFLogxK
U2 - 10.1111/j.1468-2982.2008.01704.x
DO - 10.1111/j.1468-2982.2008.01704.x
M3 - Article
C2 - 19220309
AN - SCOPUS:59149100783
VL - 29
SP - 286
EP - 292
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 3
ER -