Abstract
Migraine is a disorder typically associated with female reproductive life. It is regarded as a 'female disease' not only on the basis of the pattern of its prevalence, but also to the neuroendocrine changes related to reproductive life and possible hormonal treatments (oral contraceptives, estrogen replacement therapy) can considerably affect the clinical presentation and the natural course of the disorder. Numerous studies have been focused on the relationship between migraine and hormones, from both the pathophysiological and the clinico-epidemiological perspectives. However, no conclusive evidence is available to date on the role of hormone fluctuations in triggering pain attacks. Menstrual migraine, for instance, is a paradigm of such changes, but to explain the phenomenon of migrainous vulnerability in this definite period of the ovarian cycle it is necessary to take into account the interaction of several steroid-dependent mechanisms, both neuronal and vascular. In this short review we discuss some aspects supporting the existence of a close relationship between gonadal steroids and mechanisms of migraine within the central nervous system (CNS) of female patients. Particular emphasis is placed on the events of reproductive life and hormonal treatments, and on the usefulness of an integrated approach by neurologists and gynaecologists in the management of migraine in woman.
| Original language | Italian |
|---|---|
| Pages (from-to) | 9-16 |
| Number of pages | 8 |
| Journal | Confinia Cephalalgica |
| Volume | 9 |
| Issue number | 1 |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Emicrania e ormoni gonadici femminili : Implicazioni per il sistema nervoso centrale. / Nappi, R. E.; Veneroni, F.; Chiapparini, I.; Sances, G.; Costa, A.; Farina, C.; Fignon, A.; Polatti, F.
In: Confinia Cephalalgica, Vol. 9, No. 1, 2000, p. 9-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emicrania e ormoni gonadici femminili
T2 - Implicazioni per il sistema nervoso centrale
AU - Nappi, R. E.
AU - Veneroni, F.
AU - Chiapparini, I.
AU - Sances, G.
AU - Costa, A.
AU - Farina, C.
AU - Fignon, A.
AU - Polatti, F.
PY - 2000
Y1 - 2000
N2 - Migraine is a disorder typically associated with female reproductive life. It is regarded as a 'female disease' not only on the basis of the pattern of its prevalence, but also to the neuroendocrine changes related to reproductive life and possible hormonal treatments (oral contraceptives, estrogen replacement therapy) can considerably affect the clinical presentation and the natural course of the disorder. Numerous studies have been focused on the relationship between migraine and hormones, from both the pathophysiological and the clinico-epidemiological perspectives. However, no conclusive evidence is available to date on the role of hormone fluctuations in triggering pain attacks. Menstrual migraine, for instance, is a paradigm of such changes, but to explain the phenomenon of migrainous vulnerability in this definite period of the ovarian cycle it is necessary to take into account the interaction of several steroid-dependent mechanisms, both neuronal and vascular. In this short review we discuss some aspects supporting the existence of a close relationship between gonadal steroids and mechanisms of migraine within the central nervous system (CNS) of female patients. Particular emphasis is placed on the events of reproductive life and hormonal treatments, and on the usefulness of an integrated approach by neurologists and gynaecologists in the management of migraine in woman.
AB - Migraine is a disorder typically associated with female reproductive life. It is regarded as a 'female disease' not only on the basis of the pattern of its prevalence, but also to the neuroendocrine changes related to reproductive life and possible hormonal treatments (oral contraceptives, estrogen replacement therapy) can considerably affect the clinical presentation and the natural course of the disorder. Numerous studies have been focused on the relationship between migraine and hormones, from both the pathophysiological and the clinico-epidemiological perspectives. However, no conclusive evidence is available to date on the role of hormone fluctuations in triggering pain attacks. Menstrual migraine, for instance, is a paradigm of such changes, but to explain the phenomenon of migrainous vulnerability in this definite period of the ovarian cycle it is necessary to take into account the interaction of several steroid-dependent mechanisms, both neuronal and vascular. In this short review we discuss some aspects supporting the existence of a close relationship between gonadal steroids and mechanisms of migraine within the central nervous system (CNS) of female patients. Particular emphasis is placed on the events of reproductive life and hormonal treatments, and on the usefulness of an integrated approach by neurologists and gynaecologists in the management of migraine in woman.
KW - Central nervous system
KW - Estrogens
KW - Hormonal replacement therapy
KW - Menopause
KW - Menstrual cycle
KW - Migraine
KW - Progestagens
UR - http://www.scopus.com/inward/record.url?scp=0033832283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033832283&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0033832283
VL - 9
SP - 9
EP - 16
JO - Confinia Cephalalgica
JF - Confinia Cephalalgica
SN - 1122-0279
IS - 1
ER -