Emicrania e ormoni gonadici femminili: Implicazioni per il sistema nervoso centrale

Translated title of the contribution: Migraine mechanisms and female hormones: Implications for the central nervous system

R. E. Nappi, F. Veneroni, I. Chiapparini, G. Sances, A. Costa, C. Farina, A. Fignon, F. Polatti

Research output: Contribution to journalArticle

Abstract

Migraine is a disorder typically associated with female reproductive life. It is regarded as a 'female disease' not only on the basis of the pattern of its prevalence, but also to the neuroendocrine changes related to reproductive life and possible hormonal treatments (oral contraceptives, estrogen replacement therapy) can considerably affect the clinical presentation and the natural course of the disorder. Numerous studies have been focused on the relationship between migraine and hormones, from both the pathophysiological and the clinico-epidemiological perspectives. However, no conclusive evidence is available to date on the role of hormone fluctuations in triggering pain attacks. Menstrual migraine, for instance, is a paradigm of such changes, but to explain the phenomenon of migrainous vulnerability in this definite period of the ovarian cycle it is necessary to take into account the interaction of several steroid-dependent mechanisms, both neuronal and vascular. In this short review we discuss some aspects supporting the existence of a close relationship between gonadal steroids and mechanisms of migraine within the central nervous system (CNS) of female patients. Particular emphasis is placed on the events of reproductive life and hormonal treatments, and on the usefulness of an integrated approach by neurologists and gynaecologists in the management of migraine in woman.

Original languageItalian
Pages (from-to)9-16
Number of pages8
JournalConfinia Cephalalgica
Volume9
Issue number1
Publication statusPublished - 2000

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Migraine Disorders
Central Nervous System
Hormones
Contraceptives, Oral, Hormonal
Steroids
Estrogen Replacement Therapy
Menstrual Cycle
Blood Vessels
Pain
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Emicrania e ormoni gonadici femminili : Implicazioni per il sistema nervoso centrale. / Nappi, R. E.; Veneroni, F.; Chiapparini, I.; Sances, G.; Costa, A.; Farina, C.; Fignon, A.; Polatti, F.

In: Confinia Cephalalgica, Vol. 9, No. 1, 2000, p. 9-16.

Research output: Contribution to journalArticle

Nappi, RE, Veneroni, F, Chiapparini, I, Sances, G, Costa, A, Farina, C, Fignon, A & Polatti, F 2000, 'Emicrania e ormoni gonadici femminili: Implicazioni per il sistema nervoso centrale', Confinia Cephalalgica, vol. 9, no. 1, pp. 9-16.
Nappi, R. E. ; Veneroni, F. ; Chiapparini, I. ; Sances, G. ; Costa, A. ; Farina, C. ; Fignon, A. ; Polatti, F. / Emicrania e ormoni gonadici femminili : Implicazioni per il sistema nervoso centrale. In: Confinia Cephalalgica. 2000 ; Vol. 9, No. 1. pp. 9-16.
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