Migraine preventive therapy: Selection of appropriate patients and general principles of management

Domenico D'Amico, Michel Lanteri-Minet

Research output: Contribution to journalArticlepeer-review


The goal of this review is to communicate the rationale and the possible benefits of migraine preventive treatments to clinicians and patients, and to address the many problematic issues created by missed diagnosis or misdiagnoses and inadequate migraine management. Successful implementation of migraine preventive treatment requires appropriate patient selection based on several factors, including the frequency of migraine attacks (≥2-3 attacks/month), the level of disability incurred and the frequency of acute medication usage. Unfortunately, several epidemiologic surveys indicate that preventive therapies are significantly underutilized, which supports the need for greater dialog concerning migraine prevention between consumers and physicians. Effective migraine preventive therapy should reduce the frequency, duration, and severity of migraine, and also improve function, reduce disability, and possibly reduce the risk of worsening the headache syndrome, through acute medication overuse.

Original languageEnglish
Pages (from-to)1147-1157
Number of pages11
JournalExpert Review of Neurotherapeutics
Issue number8
Publication statusPublished - 2006


  • Headache
  • Migraine
  • Prevention
  • Prophylaxis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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