Migraine-specific quality of life questionnaire and relapse of medication overuse headache

Stefano Caproni, Elisa Bianchi, Letizia M. Cupini, Ilenia Corbelli, Ettore Beghi, Paolo Calabresi, Paola Sarchielli

Research output: Contribution to journalArticlepeer-review


Background: The management of Medication overuse headache (MOH) represents a difficult challenge for clinicians and headache experts, particularly for the responder rate after a successful withdrawal treatment. The purpose of this study was to investigate the role of demographic and clinical characteristics as well as the score of Migraine-Specific Quality of Life Questionnaire (MSQ), Migraine Disability Questionnaire and Leeds Dependence Questionnaire in predicting a response after a successful withdrawal treatment in patients with MOH. Methods: This ancillary study is part of a randomized trial that demonstrated the safety and the efficacy of a 3-month treatment with sodium valproate (VPA) (800 mg/day vs placebo) in MOH. Demographic and clinical characteristics and questionnaire results were obtained from the entire sample. Results: A significant correlation was found only between MOH relapse and the total MSQ score, the Role Preventive sub-scale and the Emotional Function sub-scale, suggesting a poorer quality of life in non responders. Conclusion: A high MSQ score could be associated with a poor short-term outcome in MOH patients after a successful treatment with detoxification followed by a new treatment.

Original languageEnglish
JournalBMC Neurology
Publication statusAccepted/In press - May 21 2015


  • MOH
  • MSQ
  • Relapse

ASJC Scopus subject areas

  • Clinical Neurology


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