Migratory capacity of large granular lymphocytes from T-gamma-lymphoproliferative disorders

B. Bottazzi, A. Rambaldi, M. Introna, A. Merendino, F. Piovella, R. Bassan, P. Viero, T. Barbui, A. Mantovani

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The authors have investigated 10 patients with Tγ-lymphoproliferative disorders (TγLPD) for cell migratory capacity. Large granular lymphocytes (LGLs) expanding in these subjects expressed natural killer cell markers (HNKI, B73.1, AB8.28, N901, OKM1) to a variable extent. The patients' LGLs mediated antibody-dependent cellular ytotoxicity, while appreciable natural killer activity was only measurable in 3 patients.The migratory capacity of TyLPD was examined by using nitrocellulose filters. The patients' LGLs migrated into filters and showed responsiveness (in 9 of 10 patients) to activated serum, used as chemoattractant, as normal LGLs do. No clearcut correlation emerged between in vitro migratory capacity and disease aggressiveness or involvement of abdominal organs. These results confirm in TγLPD the migratory potential of LGLs and suggest the possibility that acquisition of enhanced locomotor capacity is not a crucial determinant of disease aggressiveness in TγLPD.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalNatural Immunity and Cell Growth Regulation
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry


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