Milan Ultrasound Criteria are accurate in assessing disease activity in ulcerative colitis: External validation

Mariangela Allocca; Elisabetta Filippi; Andrea Costantino; Stefanos Bonovas; Gionata Fiorino; Federica Furfaro; Laurent Peyrin-Biroulet; Mirella Fraquelli; Flavio Caprioli; Silvio Danese

doi:10.1177/2050640620980203

Milan Ultrasound Criteria are accurate in assessing disease activity in ulcerative colitis: External validation

Mariangela Allocca, Elisabetta Filippi, Andrea Costantino, Stefanos Bonovas, Gionata Fiorino, Federica Furfaro, Laurent Peyrin-Biroulet, Mirella Fraquelli, Flavio Caprioli, Silvio Danese

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: The aim of this study was to provide an external validation of bowel ultrasound (US) predictors of activity in ulcerative colitis (UC) and quantitative Milan Ultrasound Criteria (MUC).

METHODS: Forty-three consecutive patients with UC (16 in endoscopic remission and 27 with endoscopic activity) underwent bowel US and colonoscopy in a tertiary referral inflammatory bowel disease unit.

RESULTS: A MUC score >6.2 discriminated patients with active versus non-active UC with a sensitivity of 0.85 (95% confidence interval (CI) 0.66‒0.96), specificity of 0.94 (95% CI 0.70‒0.99) and an area under the curve of 0.902 (95% CI 0.772‒0.971) in complete agreement with the derivation study.

CONCLUSION: The external validation of MUC confirms that it is an accurate tool for assessing disease activity in patients with UC.

Original language	English
Pages (from-to)	2050640620980203
Journal	United European Gastroenterology Journal
DOIs	https://doi.org/10.1177/2050640620980203
Publication status	E-pub ahead of print - Dec 21 2020

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Milan Ultrasound Criteria are accurate in assessing disease activity in ulcerative colitis : External validation. / Allocca, Mariangela; Filippi, Elisabetta; Costantino, Andrea; Bonovas, Stefanos ; Fiorino, Gionata ; Furfaro, Federica; Peyrin-Biroulet, Laurent; Fraquelli, Mirella ; Caprioli, Flavio ; Danese, Silvio.

In: United European Gastroenterology Journal, 21.12.2020, p. 2050640620980203.

Research output: Contribution to journal › Article › peer-review

Allocca, Mariangela ; Filippi, Elisabetta ; Costantino, Andrea ; Bonovas, Stefanos ; Fiorino, Gionata ; Furfaro, Federica ; Peyrin-Biroulet, Laurent ; Fraquelli, Mirella ; Caprioli, Flavio ; Danese, Silvio. / Milan Ultrasound Criteria are accurate in assessing disease activity in ulcerative colitis : External validation. In: United European Gastroenterology Journal. 2020 ; pp. 2050640620980203.

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title = "Milan Ultrasound Criteria are accurate in assessing disease activity in ulcerative colitis: External validation",

abstract = "INTRODUCTION: The aim of this study was to provide an external validation of bowel ultrasound (US) predictors of activity in ulcerative colitis (UC) and quantitative Milan Ultrasound Criteria (MUC).METHODS: Forty-three consecutive patients with UC (16 in endoscopic remission and 27 with endoscopic activity) underwent bowel US and colonoscopy in a tertiary referral inflammatory bowel disease unit.RESULTS: A MUC score >6.2 discriminated patients with active versus non-active UC with a sensitivity of 0.85 (95% confidence interval (CI) 0.66‒0.96), specificity of 0.94 (95% CI 0.70‒0.99) and an area under the curve of 0.902 (95% CI 0.772‒0.971) in complete agreement with the derivation study.CONCLUSION: The external validation of MUC confirms that it is an accurate tool for assessing disease activity in patients with UC.",

author = "Mariangela Allocca and Elisabetta Filippi and Andrea Costantino and Stefanos Bonovas and Gionata Fiorino and Federica Furfaro and Laurent Peyrin-Biroulet and Mirella Fraquelli and Flavio Caprioli and Silvio Danese",

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T1 - Milan Ultrasound Criteria are accurate in assessing disease activity in ulcerative colitis

T2 - External validation

AU - Allocca, Mariangela

AU - Filippi, Elisabetta

AU - Costantino, Andrea

AU - Bonovas, Stefanos

AU - Fiorino, Gionata

AU - Furfaro, Federica

AU - Peyrin-Biroulet, Laurent

AU - Fraquelli, Mirella

AU - Caprioli, Flavio

AU - Danese, Silvio

PY - 2020/12/21

Y1 - 2020/12/21

N2 - INTRODUCTION: The aim of this study was to provide an external validation of bowel ultrasound (US) predictors of activity in ulcerative colitis (UC) and quantitative Milan Ultrasound Criteria (MUC).METHODS: Forty-three consecutive patients with UC (16 in endoscopic remission and 27 with endoscopic activity) underwent bowel US and colonoscopy in a tertiary referral inflammatory bowel disease unit.RESULTS: A MUC score >6.2 discriminated patients with active versus non-active UC with a sensitivity of 0.85 (95% confidence interval (CI) 0.66‒0.96), specificity of 0.94 (95% CI 0.70‒0.99) and an area under the curve of 0.902 (95% CI 0.772‒0.971) in complete agreement with the derivation study.CONCLUSION: The external validation of MUC confirms that it is an accurate tool for assessing disease activity in patients with UC.

AB - INTRODUCTION: The aim of this study was to provide an external validation of bowel ultrasound (US) predictors of activity in ulcerative colitis (UC) and quantitative Milan Ultrasound Criteria (MUC).METHODS: Forty-three consecutive patients with UC (16 in endoscopic remission and 27 with endoscopic activity) underwent bowel US and colonoscopy in a tertiary referral inflammatory bowel disease unit.RESULTS: A MUC score >6.2 discriminated patients with active versus non-active UC with a sensitivity of 0.85 (95% confidence interval (CI) 0.66‒0.96), specificity of 0.94 (95% CI 0.70‒0.99) and an area under the curve of 0.902 (95% CI 0.772‒0.971) in complete agreement with the derivation study.CONCLUSION: The external validation of MUC confirms that it is an accurate tool for assessing disease activity in patients with UC.

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DO - 10.1177/2050640620980203

M3 - Article

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JF - United European Gastroenterology Journal

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