Milan Ultrasound Criteria are accurate in assessing disease activity in ulcerative colitis: External validation

Mariangela Allocca, Elisabetta Filippi, Andrea Costantino, Stefanos Bonovas, Gionata Fiorino, Federica Furfaro, Laurent Peyrin-Biroulet, Mirella Fraquelli, Flavio Caprioli, Silvio Danese

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: The aim of this study was to provide an external validation of bowel ultrasound (US) predictors of activity in ulcerative colitis (UC) and quantitative Milan Ultrasound Criteria (MUC).

METHODS: Forty-three consecutive patients with UC (16 in endoscopic remission and 27 with endoscopic activity) underwent bowel US and colonoscopy in a tertiary referral inflammatory bowel disease unit.

RESULTS: A MUC score >6.2 discriminated patients with active versus non-active UC with a sensitivity of 0.85 (95% confidence interval (CI) 0.66‒0.96), specificity of 0.94 (95% CI 0.70‒0.99) and an area under the curve of 0.902 (95% CI 0.772‒0.971) in complete agreement with the derivation study.

CONCLUSION: The external validation of MUC confirms that it is an accurate tool for assessing disease activity in patients with UC.

Original languageEnglish
Pages (from-to)2050640620980203
JournalUnited European Gastroenterology Journal
DOIs
Publication statusE-pub ahead of print - Dec 21 2020

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