TY - JOUR
T1 - Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats
AU - Sancesario, Giuseppe
AU - Pietroiusti, Antonio
AU - Cestaro, Benvenuto
AU - Fusco, Francesca Romana
AU - Magrini, Andrea
AU - Patacchioli, Francesca Romana
AU - Franceschelli, Laura
AU - Galante, Alberto
PY - 1997/9
Y1 - 1997/9
N2 - This study evaluated local and systemic leukocyte changes, respectively in the jugular and femoral veins, after an acute reduction of cerebral blood flow (oligoemia) in rats submitted either to permanent bilateral carotid occlusion (BCO) (no. = 36) for 5 hours or to sham operation (no. = 33). In a subgroup of rats (no. = 13) the extent of neural damage was histologically assessed. As a marker of biochemical brain changes the entity of the iron- ascorbate induced lipid peroxidation of synaptosomes was assessed in vitro by measuring malondialdehyde (MDA) reactive products. Five hours after surgery, the percentage of aggregated leukocytes and of activated neutrophils reducing the NBT were significantly higher in BCO rats (p
AB - This study evaluated local and systemic leukocyte changes, respectively in the jugular and femoral veins, after an acute reduction of cerebral blood flow (oligoemia) in rats submitted either to permanent bilateral carotid occlusion (BCO) (no. = 36) for 5 hours or to sham operation (no. = 33). In a subgroup of rats (no. = 13) the extent of neural damage was histologically assessed. As a marker of biochemical brain changes the entity of the iron- ascorbate induced lipid peroxidation of synaptosomes was assessed in vitro by measuring malondialdehyde (MDA) reactive products. Five hours after surgery, the percentage of aggregated leukocytes and of activated neutrophils reducing the NBT were significantly higher in BCO rats (p
KW - Activation neurotrophils
KW - Brain oligoemia
KW - Free radicals
KW - Leukocyte aggregation
KW - Neuronal death
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M3 - Article
C2 - 9439946
AN - SCOPUS:0031437948
VL - 12
SP - 283
EP - 291
JO - Functional Neurology
JF - Functional Neurology
SN - 0393-5264
IS - 5
ER -