Abstract
This study evaluated local and systemic leukocyte changes, respectively in the jugular and femoral veins, after an acute reduction of cerebral blood flow (oligoemia) in rats submitted either to permanent bilateral carotid occlusion (BCO) (no. = 36) for 5 hours or to sham operation (no. = 33). In a subgroup of rats (no. = 13) the extent of neural damage was histologically assessed. As a marker of biochemical brain changes the entity of the iron- ascorbate induced lipid peroxidation of synaptosomes was assessed in vitro by measuring malondialdehyde (MDA) reactive products. Five hours after surgery, the percentage of aggregated leukocytes and of activated neutrophils reducing the NBT were significantly higher in BCO rats (p
| Original language | English |
|---|---|
| Pages (from-to) | 283-291 |
| Number of pages | 9 |
| Journal | Functional Neurology |
| Volume | 12 |
| Issue number | 5 |
| Publication status | Published - Sep 1997 |
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Keywords
- Activation neurotrophils
- Brain oligoemia
- Free radicals
- Leukocyte aggregation
- Neuronal death
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Sancesario, G., Pietroiusti, A., Cestaro, B., Fusco, F. R., Magrini, A., Patacchioli, F. R., Franceschelli, L., & Galante, A. (1997). Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats. Functional Neurology, 12(5), 283-291.