Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats

Giuseppe Sancesario, Antonio Pietroiusti, Benvenuto Cestaro, Francesca Romana Fusco, Andrea Magrini, Francesca Romana Patacchioli, Laura Franceschelli, Alberto Galante

Research output: Contribution to journalArticle

Abstract

This study evaluated local and systemic leukocyte changes, respectively in the jugular and femoral veins, after an acute reduction of cerebral blood flow (oligoemia) in rats submitted either to permanent bilateral carotid occlusion (BCO) (no. = 36) for 5 hours or to sham operation (no. = 33). In a subgroup of rats (no. = 13) the extent of neural damage was histologically assessed. As a marker of biochemical brain changes the entity of the iron- ascorbate induced lipid peroxidation of synaptosomes was assessed in vitro by measuring malondialdehyde (MDA) reactive products. Five hours after surgery, the percentage of aggregated leukocytes and of activated neutrophils reducing the NBT were significantly higher in BCO rats (p

Original languageEnglish
Pages (from-to)283-291
Number of pages9
JournalFunctional Neurology
Volume12
Issue number5
Publication statusPublished - Sep 1997

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Keywords

  • Activation neurotrophils
  • Brain oligoemia
  • Free radicals
  • Leukocyte aggregation
  • Neuronal death

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sancesario, G., Pietroiusti, A., Cestaro, B., Fusco, F. R., Magrini, A., Patacchioli, F. R., Franceschelli, L., & Galante, A. (1997). Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats. Functional Neurology, 12(5), 283-291.