Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats

Giuseppe Sancesario; Antonio Pietroiusti; Benvenuto Cestaro; Francesca Romana Fusco; Andrea Magrini; Francesca Romana Patacchioli; Laura Franceschelli; Alberto Galante

Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats

Giuseppe Sancesario, Antonio Pietroiusti, Benvenuto Cestaro, Francesca Romana Fusco, Andrea Magrini, Francesca Romana Patacchioli, Laura Franceschelli, Alberto Galante

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

This study evaluated local and systemic leukocyte changes, respectively in the jugular and femoral veins, after an acute reduction of cerebral blood flow (oligoemia) in rats submitted either to permanent bilateral carotid occlusion (BCO) (no. = 36) for 5 hours or to sham operation (no. = 33). In a subgroup of rats (no. = 13) the extent of neural damage was histologically assessed. As a marker of biochemical brain changes the entity of the iron- ascorbate induced lipid peroxidation of synaptosomes was assessed in vitro by measuring malondialdehyde (MDA) reactive products. Five hours after surgery, the percentage of aggregated leukocytes and of activated neutrophils reducing the NBT were significantly higher in BCO rats (p

Original language	English
Pages (from-to)	283-291
Number of pages	9
Journal	Functional Neurology
Volume	12
Issue number	5
Publication status	Published - Sep 1997

Keywords

Activation neurotrophils
Brain oligoemia
Free radicals
Leukocyte aggregation
Neuronal death

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats. / Sancesario, Giuseppe; Pietroiusti, Antonio; Cestaro, Benvenuto; Fusco, Francesca Romana; Magrini, Andrea; Patacchioli, Francesca Romana; Franceschelli, Laura; Galante, Alberto.

In: Functional Neurology, Vol. 12, No. 5, 09.1997, p. 283-291.

Research output: Contribution to journal › Article › peer-review

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AU - Magrini, Andrea

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AU - Franceschelli, Laura

AU - Galante, Alberto

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Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats

Abstract

Keywords

ASJC Scopus subject areas

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