Mild ciguatera poisoning: Case reports with neurophysiological evaluations

Raffaella Butera, Leon D. Prockop, Michelangelo Buonocore, Carlo Locatelli, Cristiano Gandini, Luigi Manzo

Research output: Contribution to journalArticlepeer-review


Ciguatera poisoning causes mainly gastrointestinal and neurological effects of variable severity. However, symptoms of peripheral neuropathy with paresthesias and paradoxical disturbance of thermal sensation are the hallmark. Electrophysiological studies are often normal, except in severe cases. We report four people who developed mild ciguatera poisoning after barracuda ingestion. Electrophysiological studies documented normocalcemic latent tetany. These findings are consistent with ciguatoxin's mechanism of toxicity, which involves inactivation of voltage-gated Na+ channels and eventually increases nerve membrane excitability. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish
Pages (from-to)1598-1603
Number of pages6
JournalMuscle and Nerve
Issue number10
Publication statusPublished - 2000


  • Ciguatera fish poisoning
  • Latent tetany
  • Mannitol
  • Nerve conduction
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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