Abstract
OBJECTIVES: To identify subjects with minimal or mild nonamnestic cognitive impairment with parkinsonian stance and gait and investigate vascular correlates of this condition. DESIGN: First wave of an epidemiological longitudinal study (InCHIANTI) on factors predicting loss of mobility in older persons. SETTING: The Chianti geographic area (Tuscany, Italy). PARTICIPANTS: Five hundred fifty-six subjects aged 70 to 90 with Mini-Mental State Examination (MMSE) scores greater than 23 of 30, of the 1,260 persons aged 65 and older randomly selected from the population registry of Greve in Chianti and Bagno a Ripoli, two small towns near Florence. METHODS: Low cognitive performance (LCP) was defined as an age- and education-adjusted MMSE below the 50th percentile for the InCHIANTI population. Subcortical features were plastic rigidity on neurological examination (parkinsonism), gait disturbance (small-step gait or parkinsonian gait), and dysexecutive features. Two hundred forty-three participants had high cognitive performance, 166 had LCP without subcortical features, and 75 had LCP with subcortical features. Vascular risk factors were hypertension, atrial fibrillation or pathological findings on electrocardiogram (ECG), low serum high-density lipoprotein (HDL) or high low-density lipoprotein cholesterol, diabetes mellitus, obesity, and heavy smoking. RESULTS: Three main vascular risk factors were significantly more prevalent in LCP with subcortical features: hypertension (P = .02), atrial fibrillation or ECG changes (P = .04), and low HDL cholesterol (P = .001). LCP with subcortical features was significantly associated with cerebrovascular risk factors (P = .001). CONCLUSION: Gait disturbance and nonamnestic cognitive symptoms might be the consequence of subcortical vascular damage.
| Original language | English |
|---|---|
| Pages (from-to) | 1064-1071 |
| Number of pages | 8 |
| Journal | Journal of the American Geriatrics Society |
| Volume | 51 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2003 |
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Keywords
- Cognitive impairment
- Parkinsonism
- Subcortical features
- Vascular risk factor
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Mild cognitive deterioration with subcortical features : Prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (the InCHIANTI study). / Geroldi, Cristina; Ferrucci, Luigi; Bandinelli, Stefania; Cavazzini, Chiara; Zanetti, Orazio; Guralnik, Jack M.; Frisoni, Giovanni B.
In: Journal of the American Geriatrics Society, Vol. 51, No. 8, 01.08.2003, p. 1064-1071.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mild cognitive deterioration with subcortical features
T2 - Prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (the InCHIANTI study)
AU - Geroldi, Cristina
AU - Ferrucci, Luigi
AU - Bandinelli, Stefania
AU - Cavazzini, Chiara
AU - Zanetti, Orazio
AU - Guralnik, Jack M.
AU - Frisoni, Giovanni B.
PY - 2003/8/1
Y1 - 2003/8/1
N2 - OBJECTIVES: To identify subjects with minimal or mild nonamnestic cognitive impairment with parkinsonian stance and gait and investigate vascular correlates of this condition. DESIGN: First wave of an epidemiological longitudinal study (InCHIANTI) on factors predicting loss of mobility in older persons. SETTING: The Chianti geographic area (Tuscany, Italy). PARTICIPANTS: Five hundred fifty-six subjects aged 70 to 90 with Mini-Mental State Examination (MMSE) scores greater than 23 of 30, of the 1,260 persons aged 65 and older randomly selected from the population registry of Greve in Chianti and Bagno a Ripoli, two small towns near Florence. METHODS: Low cognitive performance (LCP) was defined as an age- and education-adjusted MMSE below the 50th percentile for the InCHIANTI population. Subcortical features were plastic rigidity on neurological examination (parkinsonism), gait disturbance (small-step gait or parkinsonian gait), and dysexecutive features. Two hundred forty-three participants had high cognitive performance, 166 had LCP without subcortical features, and 75 had LCP with subcortical features. Vascular risk factors were hypertension, atrial fibrillation or pathological findings on electrocardiogram (ECG), low serum high-density lipoprotein (HDL) or high low-density lipoprotein cholesterol, diabetes mellitus, obesity, and heavy smoking. RESULTS: Three main vascular risk factors were significantly more prevalent in LCP with subcortical features: hypertension (P = .02), atrial fibrillation or ECG changes (P = .04), and low HDL cholesterol (P = .001). LCP with subcortical features was significantly associated with cerebrovascular risk factors (P = .001). CONCLUSION: Gait disturbance and nonamnestic cognitive symptoms might be the consequence of subcortical vascular damage.
AB - OBJECTIVES: To identify subjects with minimal or mild nonamnestic cognitive impairment with parkinsonian stance and gait and investigate vascular correlates of this condition. DESIGN: First wave of an epidemiological longitudinal study (InCHIANTI) on factors predicting loss of mobility in older persons. SETTING: The Chianti geographic area (Tuscany, Italy). PARTICIPANTS: Five hundred fifty-six subjects aged 70 to 90 with Mini-Mental State Examination (MMSE) scores greater than 23 of 30, of the 1,260 persons aged 65 and older randomly selected from the population registry of Greve in Chianti and Bagno a Ripoli, two small towns near Florence. METHODS: Low cognitive performance (LCP) was defined as an age- and education-adjusted MMSE below the 50th percentile for the InCHIANTI population. Subcortical features were plastic rigidity on neurological examination (parkinsonism), gait disturbance (small-step gait or parkinsonian gait), and dysexecutive features. Two hundred forty-three participants had high cognitive performance, 166 had LCP without subcortical features, and 75 had LCP with subcortical features. Vascular risk factors were hypertension, atrial fibrillation or pathological findings on electrocardiogram (ECG), low serum high-density lipoprotein (HDL) or high low-density lipoprotein cholesterol, diabetes mellitus, obesity, and heavy smoking. RESULTS: Three main vascular risk factors were significantly more prevalent in LCP with subcortical features: hypertension (P = .02), atrial fibrillation or ECG changes (P = .04), and low HDL cholesterol (P = .001). LCP with subcortical features was significantly associated with cerebrovascular risk factors (P = .001). CONCLUSION: Gait disturbance and nonamnestic cognitive symptoms might be the consequence of subcortical vascular damage.
KW - Cognitive impairment
KW - Parkinsonism
KW - Subcortical features
KW - Vascular risk factor
UR - http://www.scopus.com/inward/record.url?scp=0042743756&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042743756&partnerID=8YFLogxK
U2 - 10.1046/j.1532-5415.2003.51353.x
DO - 10.1046/j.1532-5415.2003.51353.x
M3 - Article
C2 - 12890067
AN - SCOPUS:0042743756
VL - 51
SP - 1064
EP - 1071
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 8
ER -