Mild cognitive impairment in patients with moderate to severe chronic plaque psoriasis

Paolo Gisondi, Francesca Sala, Franco Alessandrini, Virginia Avesani, Giada Zoccatelli, Alberto Beltramello, Giuseppe Moretto, Giuseppe Gambina, Giampiero Girolomoni

Research output: Contribution to journalArticle


Background: Psoriasis is frequently associated with cardiometabolic comorbidities and depression that are risk factors for cognitive impairment. Objective: To investigate cognitive performance in psoriatic patients. Method: Cognitive performances were assessed by neuropsychological tests in 41 patients with psoriasis and 37 controls. Diagnostic criteria for mild cognitive impairment (MCI) were (1) subjective complaint of a memory deficit, confirmed by a relative or caregiver, (2) pathological performance on neuropsychological tests investigating cognitive domains, (3) normal performance of daily living activities and (4) no dementia. Neuroimaging was studied by high-field magnetic resonance imaging and cortical thickness analysis. Results: MCI was found in 18 out of 41 (44%) patients with psoriasis compared to 4 out of 37 (11%) controls (p = 0.002). In particular, patients with psoriasis had lower scores in the delayed recall of the Rey Auditory Verbal Learning Test (p = 0.04), Backwards Digit Span Test (p = 0.002), Weigl's Sorting Test (p = 0.01) and Trail Making Test B (p = 0.008). In the 7 patients submitted to cortical thickness analysis, a reduction in brain thickness in parahippocampal, superior temporal and frontal gyri of the left hemisphere was observed. Conclusions: Patients with psoriasis may have a precocious impairment of long-term verbal memory, executive functions and attention.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
Issue number1
Publication statusPublished - Feb 2014


  • Brain imaging
  • Dementia screening
  • Diffusion tensor imaging
  • Mild cognitive impairment
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Gisondi, P., Sala, F., Alessandrini, F., Avesani, V., Zoccatelli, G., Beltramello, A., Moretto, G., Gambina, G., & Girolomoni, G. (2014). Mild cognitive impairment in patients with moderate to severe chronic plaque psoriasis. Dermatology, 228(1), 78-85.