Mild cognitive impairment with subcortical vascular features

Clinical characteristics and outcome

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Objectives: To identify non-demented individuals with cognitive impairment due to a cerebrovascular etiology among those coming to observation of a memory clinic and to describe their clinical features and outcome. Methods: Patients were enrolled in a prospective study on early cognitive impairment carried out in a Memory Clinic. Mild cognitive impairment of the vascular type (MCI-V) was defined based on modified criteria for subcortical vascular dementia (SVD) by Erkinjuntti and colleagues. Twenty-nine patients with MCI-V (age 78 ± 7, Mini Mental State Exam (MMSE) 24 ± 3) were compared with 14 with mild cognitive impairment of degenerative etiology (MCI) based on the Mayo Clinic criteria (age 72 ± 9, MMSE 25 ± 2), and to 21 patients with frank SVD (age 80 ± 6, MMSE 21 ± 3). Patients were followed over time for 32 ± 8 months. Results: MCI-V patients had a neuropsychological profile characterized by poor performance on frontal tests (Wisconsin card sorting and word fluency) and neurological features of parkinsonism without tremor (impairment of balance and gait). Of those followed for at least 40 months, 50% of patients with MCI-V and SVD had died, while all MCI patients were still alive (P = 0.03). Of those alive, 68% of the MCI-V, 52% of the SVD, and 17% of the MCI patients had reached one of the following outcomes at 40 months: nursing home placement, functional loss, and cognitive deterioration (P = 0.02). Conclusions: Patients with MCI-V have a distinctive clinical picture and can be identified in a clinical setting. Because of the high frequency of adverse outcomes, very early preventive measures need to be devised.

Original languageEnglish
Pages (from-to)1423-1432
Number of pages10
JournalJournal of Neurology
Volume249
Issue number10
DOIs
Publication statusPublished - 2002

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Blood Vessels
Vascular Dementia
Cognitive Dysfunction
Parkinsonian Disorders
Tremor
Nursing Homes
Gait
Observation
Prospective Studies

Keywords

  • Cerebrovascular disease
  • Mild cognitive impairment
  • Subcortical vascular dementia
  • Vascular dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

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title = "Mild cognitive impairment with subcortical vascular features: Clinical characteristics and outcome",
abstract = "Objectives: To identify non-demented individuals with cognitive impairment due to a cerebrovascular etiology among those coming to observation of a memory clinic and to describe their clinical features and outcome. Methods: Patients were enrolled in a prospective study on early cognitive impairment carried out in a Memory Clinic. Mild cognitive impairment of the vascular type (MCI-V) was defined based on modified criteria for subcortical vascular dementia (SVD) by Erkinjuntti and colleagues. Twenty-nine patients with MCI-V (age 78 ± 7, Mini Mental State Exam (MMSE) 24 ± 3) were compared with 14 with mild cognitive impairment of degenerative etiology (MCI) based on the Mayo Clinic criteria (age 72 ± 9, MMSE 25 ± 2), and to 21 patients with frank SVD (age 80 ± 6, MMSE 21 ± 3). Patients were followed over time for 32 ± 8 months. Results: MCI-V patients had a neuropsychological profile characterized by poor performance on frontal tests (Wisconsin card sorting and word fluency) and neurological features of parkinsonism without tremor (impairment of balance and gait). Of those followed for at least 40 months, 50{\%} of patients with MCI-V and SVD had died, while all MCI patients were still alive (P = 0.03). Of those alive, 68{\%} of the MCI-V, 52{\%} of the SVD, and 17{\%} of the MCI patients had reached one of the following outcomes at 40 months: nursing home placement, functional loss, and cognitive deterioration (P = 0.02). Conclusions: Patients with MCI-V have a distinctive clinical picture and can be identified in a clinical setting. Because of the high frequency of adverse outcomes, very early preventive measures need to be devised.",
keywords = "Cerebrovascular disease, Mild cognitive impairment, Subcortical vascular dementia, Vascular dementia",
author = "Frisoni, {Giovanni B.} and Samantha Galluzzi and Lorena Bresciani and Orazio Zanetti and Cristina Geroldi",
year = "2002",
doi = "10.1007/s00415-002-0861-7",
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TY - JOUR

T1 - Mild cognitive impairment with subcortical vascular features

T2 - Clinical characteristics and outcome

AU - Frisoni, Giovanni B.

AU - Galluzzi, Samantha

AU - Bresciani, Lorena

AU - Zanetti, Orazio

AU - Geroldi, Cristina

PY - 2002

Y1 - 2002

N2 - Objectives: To identify non-demented individuals with cognitive impairment due to a cerebrovascular etiology among those coming to observation of a memory clinic and to describe their clinical features and outcome. Methods: Patients were enrolled in a prospective study on early cognitive impairment carried out in a Memory Clinic. Mild cognitive impairment of the vascular type (MCI-V) was defined based on modified criteria for subcortical vascular dementia (SVD) by Erkinjuntti and colleagues. Twenty-nine patients with MCI-V (age 78 ± 7, Mini Mental State Exam (MMSE) 24 ± 3) were compared with 14 with mild cognitive impairment of degenerative etiology (MCI) based on the Mayo Clinic criteria (age 72 ± 9, MMSE 25 ± 2), and to 21 patients with frank SVD (age 80 ± 6, MMSE 21 ± 3). Patients were followed over time for 32 ± 8 months. Results: MCI-V patients had a neuropsychological profile characterized by poor performance on frontal tests (Wisconsin card sorting and word fluency) and neurological features of parkinsonism without tremor (impairment of balance and gait). Of those followed for at least 40 months, 50% of patients with MCI-V and SVD had died, while all MCI patients were still alive (P = 0.03). Of those alive, 68% of the MCI-V, 52% of the SVD, and 17% of the MCI patients had reached one of the following outcomes at 40 months: nursing home placement, functional loss, and cognitive deterioration (P = 0.02). Conclusions: Patients with MCI-V have a distinctive clinical picture and can be identified in a clinical setting. Because of the high frequency of adverse outcomes, very early preventive measures need to be devised.

AB - Objectives: To identify non-demented individuals with cognitive impairment due to a cerebrovascular etiology among those coming to observation of a memory clinic and to describe their clinical features and outcome. Methods: Patients were enrolled in a prospective study on early cognitive impairment carried out in a Memory Clinic. Mild cognitive impairment of the vascular type (MCI-V) was defined based on modified criteria for subcortical vascular dementia (SVD) by Erkinjuntti and colleagues. Twenty-nine patients with MCI-V (age 78 ± 7, Mini Mental State Exam (MMSE) 24 ± 3) were compared with 14 with mild cognitive impairment of degenerative etiology (MCI) based on the Mayo Clinic criteria (age 72 ± 9, MMSE 25 ± 2), and to 21 patients with frank SVD (age 80 ± 6, MMSE 21 ± 3). Patients were followed over time for 32 ± 8 months. Results: MCI-V patients had a neuropsychological profile characterized by poor performance on frontal tests (Wisconsin card sorting and word fluency) and neurological features of parkinsonism without tremor (impairment of balance and gait). Of those followed for at least 40 months, 50% of patients with MCI-V and SVD had died, while all MCI patients were still alive (P = 0.03). Of those alive, 68% of the MCI-V, 52% of the SVD, and 17% of the MCI patients had reached one of the following outcomes at 40 months: nursing home placement, functional loss, and cognitive deterioration (P = 0.02). Conclusions: Patients with MCI-V have a distinctive clinical picture and can be identified in a clinical setting. Because of the high frequency of adverse outcomes, very early preventive measures need to be devised.

KW - Cerebrovascular disease

KW - Mild cognitive impairment

KW - Subcortical vascular dementia

KW - Vascular dementia

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