Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany

Fabrizio Aghini Lombardi, A. Pinchera, L. Antonangeli, T. Rago, L. Chiovato, S. Bargagna, B. Bertucelli, G. Ferretti, B. Sbrana, M. Marcheschi, P. Vitti

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The neuropsychological performance of schoolchildren living in areas with present and past iodine deficiency in Tuscany was investigated. Children were submitted to: a) block design subtest of the Wechsler Intelligence Scale for Children-Revised (WISC-R) and a modified version of the WISC-R coding subtest which evaluate the general neuropsychological and cognitive performance, independently from familial cultural background; b) simple reaction time (RT) session which evaluates the efficiency of the whole information processing and nervous transmission mechanisms. Neuropsychological performance was tested in 107 children living in Borgo a Mozzano, an area of mild iodine deficiency (IDA) with a median urinary iodine excretion (UIE) of 64 μg/L (mean±SD: 80.1±57). One hundred and six sex and age-matched children living in Marina di Pisa, an iodine sufficient coastal village of Tuscany (ISA) with a median UIE of 142 μg/L (mean±SD: 173±95) were used as controls. Tests for neuropsychological performance were performed in 57 children living in the village of Vagli, an area with past iodine deficiency (PIDA): 30 children born before iodine prophylaxis (Group 1), when the median UIE was 32 μg/L (mean±SD: 47±22), 27 children born after the institution of iodine prophylaxis (Group 2), when the median UIE was 109 μg/L (mean±SD:130±73). Sex and age-matched ISA-children were used as controls for each group. RTs were significantly delayed (p

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalJournal of Endocrinological Investigation
Volume18
Issue number1
DOIs
Publication statusPublished - 1995

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Iodine
Wechsler Scales
Intelligence
Neuropsychological Tests
Automatic Data Processing
Reaction Time
Control Groups

Keywords

  • endemic goiter
  • Iodine deficiency
  • neuropsychological impairment
  • thyroid function

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany. / Lombardi, Fabrizio Aghini; Pinchera, A.; Antonangeli, L.; Rago, T.; Chiovato, L.; Bargagna, S.; Bertucelli, B.; Ferretti, G.; Sbrana, B.; Marcheschi, M.; Vitti, P.

In: Journal of Endocrinological Investigation, Vol. 18, No. 1, 1995, p. 57-62.

Research output: Contribution to journalArticle

Lombardi, FA, Pinchera, A, Antonangeli, L, Rago, T, Chiovato, L, Bargagna, S, Bertucelli, B, Ferretti, G, Sbrana, B, Marcheschi, M & Vitti, P 1995, 'Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany', Journal of Endocrinological Investigation, vol. 18, no. 1, pp. 57-62. https://doi.org/10.1007/BF03349700
Lombardi, Fabrizio Aghini ; Pinchera, A. ; Antonangeli, L. ; Rago, T. ; Chiovato, L. ; Bargagna, S. ; Bertucelli, B. ; Ferretti, G. ; Sbrana, B. ; Marcheschi, M. ; Vitti, P. / Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany. In: Journal of Endocrinological Investigation. 1995 ; Vol. 18, No. 1. pp. 57-62.
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