Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report

Sabina Cenciarelli, Valeria Calbi, Federica Barzaghi, Maria Ester Bernardo, Chiara Oltolini, Maddalena Migliavacca, Vera Gallo, Francesca Tucci, Federico Fraschetta, Elena Albertazzi, Elena Sophia Fratini, Giulia Consiglieri, Stefania Giannelli, Francesca Dionisio, Claudia Sartirana, Sara Racca, Chiara Camesasca, Giovanni Peretto, Rita Daverio, Antonio EspositoFrancesco De Cobelli, Paolo Silvani, Marco Rabusin, Andrea Cara, Daria Trabattoni, Stefania Dispinseri, Gabriella Scarlatti, Lorenzo Piemonti, Vito Lampasona, Maria Pia Cicalese, Alessandro Aiuti, Francesca Ferrua

Research output: Contribution to journalArticlepeer-review

Abstract

In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.

Original languageEnglish
Article number603428
JournalFrontiers in Immunology
Volume11
DOIs
Publication statusPublished - Nov 24 2020

Keywords

  • gene therapy
  • immune reconstitution
  • primary immunodeficiencies
  • severe acute respiratory syndrome Coronavirus 2 (2019-nCoV)
  • Wiskott-Aldrich Syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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