Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction

Raffaele Antonelli Incalzi, Vincenzo Bellia, Stefania Maggi, Claudio Imperiale, Oliviero Capparella, Filippo Catalano, PierUgo Carbonin, Franco Rengo, D. L. Consales, D. Lo Nardo, P. Paggi, F. Goria, P. Fea, G. Iraldi, R. Corradi, A. Capurso, R. Flora, S. Torres, G. Venezia, M. MestoS. Semeraro, L. Belloti, A. Tansella, V. Grassi, S. Cossi, G. Guerini, C. Fantoni, M. De Martinis, L. Pini, G. Melillo, R. Battiloro, C. Gaudiosi, S. De Angelis, L. Motta, I. Alessandria, S. Savia, G. Masotti, M. Chiarlone, S. Zacchei, V. Pedone, D. Angelini, D. Cilla, E. Palummeri, M. Agretti, P. Costelli, D. Torriglia, M. Trabucchi, P. Barbisoni, F. Guerini, P. Ranieri, F. Caione, D. Caione, M. La Chiara, G. Galetti, A. Cantatore, D. Casarotti, G. Anni, F. Cacciatore, A. I. Pisacreta, C. Calabrese, G. Enzi, P. Dalla Montà, S. Peruzza, P. Albanese, F. Tiozzo, D. Olivieri, V. Bocchino, A. Comel, N. Barbarito, U. Senin, F. Amone, L. Camilli, S. Peretti, S. M. Zuccaro, M. Marchetti, L. Palleschi, M. Palleschi, C. Cieri, F. Vetta, F. Pagano, P. Ranieri, C. Romano, S. Forconi, G. Abate, G. Marotta, E. Pagni, C. Spada, C. Vergani, G. Giardini, M. C. Sandrini, I. Dallera, N. Scichilone, S. Battaglia

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Whether chronic obstructive pulmonary disease (COPD) carries a risk of cognitive dysfunction prior to the onset of arterial hypoxemia is not known. Our objective was to assess both the prevalence and main correlates of subclinical cognitive dysfunction in older patients with non-hypoxemic COPD. Methods: Home-dwelling non-demented subjects over 64 years of age consecutively attending 24 outpatient Departments of Respiratory Medicine or Geriatrics because of COPD (N=233), asthma (N=203), non-obstructive bronchitis (N=92) or chronic non-respiratory and non-dementing diseases (controls, N=1080) underwent a multidimensional assessment. Cognitive status was assessed by the Mini-Mental State Examination (MMSE). Independent correlates of MMSE6 on the 15-item Geriatric Depression Scale (OR=1.37, CI=1.16-1.62), a 6' walked distance

Original languageEnglish
Pages (from-to)395-401
Number of pages7
JournalAging clinical and experimental research
Volume14
Issue number5
Publication statusPublished - Oct 2002

Keywords

  • Asthma
  • Cognitive impairment
  • COPD
  • Elderly
  • MMSE
  • Respiratory function

ASJC Scopus subject areas

  • Ageing

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