Milk, dairy products and cancer risk (Italy)

Silvano Gallus, Francesca Bravi, Renato Talamini, Eva Negri, Maurizio Montella, Valerio Ramazzotti, Silvia Franceschi, Attilio Giacosa, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Background: Inconclusive information is available on the potential role of milk and dairy products on the risk of cancer at several sites. Methods: We analyzed data from a large and integrated network of hospital-based case-control studies in Italy on cancers of the oral cavity and pharynx (598 cases, 1491 controls), oesophagus (304 cases, 743 controls), colorectum (1953 cases, 4154 controls), larynx (460 cases, 1088 controis), breast (2569 cases, 2588 controls), ovary (1031 cases, 2411 controls) and prostate (1294 cases, 1451 controls). Results: Multivariate odds ratio (OR) for the highest consumption level of any type of milk was 0.94 (95% confidence interval, CI: 0.61-1.33) for cancers of the oral cavity and pharynx, 1.20 (95% CI: 0.76-1.90) for oesophageal, 0.77 (95% CI: 0.62-0.96) for colon, 0.80 (95% CI: 0.60-1.05) for rectal, 0.83 (95% CI: 0.56-1.21) for laryngeal, 0.91 (95% CI: 0.76-1.10) for breast, 0.89 (95% CI: 0.68-1.15) for ovarian and 1.08 (95% CI: 0.84-1.37) for prostate cancer. A significant trend in risk was found for colon cancer only. Inverse associations were observed between consumption of skim milk and cancers of colon (OR=0.84; 95% CI: 0.73-0.97), rectum (OR=0.76; 95% CI: 0.64-0.91), breast (OR=0.87; 95% CI: 0.77-0.98) and ovary (OR=0.77; 95% CI: 0.66-0.91). Conversely, whole milk consumption was directly associated with cancer of the rectum (OR=1.22; 95% CI: 1.03-1.44) and ovary (OR=1.25; 95% CI: 1.07-1.46). High consumption of cheese was inversely related to colon cancer risk (OR=0.80; 95% CI: 0.67-0.95). Conclusions: There was a modest direct association between milk and dairy products and prostate cancer, and a moderate inverse one for colorectal cancer. However, our findings indicate that milk and dairy products are not strong risk indicators for any of the cancers considered.

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalCancer Causes and Control
Volume17
Issue number4
DOIs
Publication statusPublished - May 2006

Keywords

  • Cancer
  • Dairy products
  • Milk
  • Risk factor

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

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  • Cite this

    Gallus, S., Bravi, F., Talamini, R., Negri, E., Montella, M., Ramazzotti, V., Franceschi, S., Giacosa, A., & La Vecchia, C. (2006). Milk, dairy products and cancer risk (Italy). Cancer Causes and Control, 17(4), 429-437. https://doi.org/10.1007/s10552-005-0423-2