MINCR: A long non-coding RNA shared between cancer and neurodegeneration

Cecilia Pandini, Maria Garofalo, Federica Rey, Jessica Garau, Susanna Zucca, Daisy Sproviero, Matteo Bordoni, Giulia Berzero, Annalisa Davin, Tino Emanuele Poloni, Orietta Pansarasa, Stephana Carelli, Stella Gagliardi, Cristina Cereda

Research output: Contribution to journalArticlepeer-review

Abstract

The multitasking nature of lncRNAs allows them to play a central role in both physiological and pathological conditions. Often the same lncRNA can participate in different diseases. Specifically, the MYC-induced Long non-Coding RNA MINCR is upregulated in various cancer types, while downregulated in Amyotrophic Lateral Sclerosis patients. Therefore, this work aims to investigate MINCR potential mechanisms of action and its implications in cancer and neurodegeneration in relation to its expression levels in SH-SY5Y cells through RNA-sequencing approach. Our results show that MINCR overexpression causes massive alterations in cancer-related genes, leading to disruption in many fundamental processes, such as cell cycle and growth factor signaling. On the contrary, MINCR downregulation influences a small number of genes involved in different neurodegenerative disorders, mostly concerning RNA metabolism and inflammation. Thus, understanding the cause and functional consequences of MINCR deregulation gives important insights on potential pathogenetic mechanisms both in cancer and in neurodegeneration.

Original languageEnglish
Pages (from-to)4039-4051
Number of pages13
JournalGenomics
Volume113
Issue number6
DOIs
Publication statusE-pub ahead of print - Oct 15 2021

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