Mind the gap: The mismatch between clinical and imaging metrics in ALS

Esther Verstraete, Martin R. Turner, Julian Grosskreutz, Massimo Filippi, Michael Benatar

Research output: Contribution to journalArticle

Abstract

Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and as such deliver biomarkers relevant to diagnosis, prognosis and monitoring disease progression. However, a correlation between imaging parameters and clinical metrics has thus far been inconsistent across studies. We discuss the contributing factors to this clinical-imaging correlation gap as well as its implications for future research.

Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume16
Issue number7-8
DOIs
Publication statusPublished - Nov 27 2015

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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