Mindfulness and pharmacological prophylaxis have comparable effect on biomarkers of inflammation and clinical indexes in chronic migraine with medication overuse: results at 12 months after withdrawal

Licia Grazzi, Domenico D’Amico, Alberto Raggi, Matilde Leonardi, Emilio Ciusani, Elena Corsini, Giovanni D’Andrea, Andrea Bolner, Francisco Salgado-García, Frank Andrasik, Emanuela Sansone

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic migraine (CM) is a disabling condition arising from a complex mixture of interconnected biological, psychological and social factors, and is often associated with medication overuse (MO). Mindfulness is emerging as a helpful treatment for pain, and one study showed that the longitudinal 12 months’ course of CM-MO patients that attended mindfulness-based treatment alone was similar to that of patients receiving medical prophylaxis alone; in this study, we describe the course of biomarkers of inflammation. Our results provide initial evidence of sustained similar effects on reduced concentration of biomarkers of inflammation, although not sizeable enough to reach statistical significance. Whether more intensive treatment and/or larger samples would lead to greater changes is unknown, but these encouraging preliminary findings suggest further research is warranted.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalNeurological Sciences
Volume38
DOIs
Publication statusPublished - May 1 2017

Keywords

  • Biomarkers
  • Chronic migraine
  • Interleukin-6
  • Medication overuse
  • Mindfulness

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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