Mind–Matter Interactions and the Frontal Lobes of the Brain: A Novel Neurobiological Model of Psi Inhibition

Morris Freedman, Malcolm Binns, Fuqiang Gao, Melissa Holmes, Austyn Roseborough, Stephen Strother, Antonino Vallesi, Stanley Jeffers, Claude Alain, Peter Whitehouse, Jennifer D. Ryan, Robert Chen, Michael D. Cusimano, Sandra E. Black

Research output: Contribution to journalArticlepeer-review


Context Despite a large literature on psi, which encompasses a range of experiences including putative telepathy (mind–mind connections), clairvoyance (perceiving distant objects or events), precognition (perceiving future events), and mind–matter interactions, there has been insufficient focus on the brain in relation to this controversial phenomenon. In contrast, our research is based on a novel neurobiological model suggesting that frontal brain systems act as a filter to inhibit psi and that the inhibitory mechanisms may relate to self-awareness. Objective To identify frontal brain regions that may inhibit psi. Design We used mind–matter interactions to study psi in two participants with frontal lobe damage. The experimental task was to influence numerical output of a Random Event Generator translated into movement of an arrow on a computer screen to the right or left. Brain MRI was analyzed to determine frontal volume loss. Results The primary area of lesion overlap between the participants was in the left medial middle frontal region, an area related to self-awareness, and involved Brodmann areas 9, 10, and 32. Both participants showed a significant effect in moving the arrow to the right, i.e., contralateral to the side of primary lesion overlap. Effect sizes were much larger compared to normal participants. Conclusions The medial frontal lobes may act as a biological filter to inhibit psi through mechanisms related to self-awareness. Neurobiological studies with a focus on the brain may open new avenues of research on psi and may significantly advance the state of this poorly understood field.

Original languageEnglish
Pages (from-to)76-85
Number of pages10
Issue number1
Publication statusPublished - Jan 1 2018


  • anomalous cognition
  • frontal lobes
  • mind–matter interactions
  • parapsychology
  • psi filter
  • self-awareness

ASJC Scopus subject areas

  • Analysis
  • Nursing(all)
  • Chiropractics
  • Complementary and alternative medicine


Dive into the research topics of 'Mind–Matter Interactions and the Frontal Lobes of the Brain: A Novel Neurobiological Model of Psi Inhibition'. Together they form a unique fingerprint.

Cite this