Mineralocorticoid effector mechanism in preeclampsia

Decio Armanini, Christina M. Zennaro, Luca Martella, Mariano Scali, Chiarastella Pratesi, Pasquale V. Grella, Franco Mantero

Research output: Contribution to journalArticlepeer-review

Abstract

Mineralocorticoid effector mechanisms were evaluated in 29 patients with preeclampsia and in 25 uncomplicated pregnancies by measurement of plasma aldosterone, levels of mineralocorticoid receptor (MR) in mononuclear leucocytes, and subtraction potential difference (SPD; rectal minus oral values). Mean values for plasma aldosterone were not different between the two groups, but significant differences were observed for MR (preeclampsia, 81 ± 44 receptors/cell; controls, 306 ± 168) and SPD (preeclampsia, 65 ± 7 mV; controls, 12 ± 5 mV). In six cases we determined MR, plasma aldosterone, and SPD in patients with preeclampsia before and 3 months after delivery. MR were reduced before delivery (96 ± 27 receptors/ cell), and SPD increased (64 ± 8 mV), with both parameters normalizing after delivery (MR, 242 ± 79; SPD, 14.0 ± 4 mV). Aldosterone levels returned to normal nonpregnant values after delivery. These data suggest an important role for abnormalities in mineralocorticoid effector mechanisms in the etiology of preeclampsia and could be an useful marker for diagnosis.

Original languageEnglish
Pages (from-to)946-949
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume74
Issue number4
Publication statusPublished - Apr 1992

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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