Mineralocorticoid Receptors in Metabolic Syndrome: From Physiology to Disease

Research output: Contribution to journalReview article

Abstract

Over the past decade, several studies have shown that activity of extra-renal mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue function, and cardiomyocyte contraction. In mice, abnormal activation of MR in the vasculature and in adipose tissue favors the occurrence of several components of the metabolic syndrome (MetS), such as hypertension, obesity, and glucose intolerance. Accordingly, high levels of aldosterone are associated with obesity and MetS in humans, suggesting that altered activation of aldosterone-MR system in extra-renal tissues leads to profound metabolic dysfunctions. In this context, in addition to the classical indications for heart failure and hypertension, MR antagonists (MRAs) nowadays represent a promising approach to tackle cardiovascular and metabolic disorders occurring in the MetS.

Original languageEnglish
JournalTrends in Endocrinology and Metabolism
DOIs
Publication statusE-pub ahead of print - Dec 19 2019

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Keywords

  • adipose tissue
  • atherosclerosis
  • cardiovascular disease
  • insulin resistance
  • obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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