Abstract
The mineralocorticoid receptor (MR) mediates aldosterone effects on salt homeostasis and blood pressure regulation. MR activation also promotes inflammation, cardiovascular remodelling and endothelial dysfunction, and affects adipose tissue differentiation and function. Some of these effects derive from MR activation by glucocorticoids. Recent epidemiological studies show that the incidence of metabolic syndrome increases across quartiles of aldosterone, implicating the MR as a central player in metabolic homeostasis, involving electrolyte, water and energy balance. This review summarizes the current understanding of MR-mediated effects in diverse tissues and the role of aldosterone as a cardiometabolic risk factor, and discusses the possible relationship between inappropriate MR activation (by both mineralocorticoids and glucocorticoids) and the development of metabolic syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 444-451 |
| Number of pages | 8 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 20 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Nov 2009 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Mineralocorticoid receptors in the metabolic syndrome. / Zennaro, Maria Christina; Caprio, Massimiliano; Fève, Bruno.
In: Trends in Endocrinology and Metabolism, Vol. 20, No. 9, 11.2009, p. 444-451.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mineralocorticoid receptors in the metabolic syndrome
AU - Zennaro, Maria Christina
AU - Caprio, Massimiliano
AU - Fève, Bruno
PY - 2009/11
Y1 - 2009/11
N2 - The mineralocorticoid receptor (MR) mediates aldosterone effects on salt homeostasis and blood pressure regulation. MR activation also promotes inflammation, cardiovascular remodelling and endothelial dysfunction, and affects adipose tissue differentiation and function. Some of these effects derive from MR activation by glucocorticoids. Recent epidemiological studies show that the incidence of metabolic syndrome increases across quartiles of aldosterone, implicating the MR as a central player in metabolic homeostasis, involving electrolyte, water and energy balance. This review summarizes the current understanding of MR-mediated effects in diverse tissues and the role of aldosterone as a cardiometabolic risk factor, and discusses the possible relationship between inappropriate MR activation (by both mineralocorticoids and glucocorticoids) and the development of metabolic syndrome.
AB - The mineralocorticoid receptor (MR) mediates aldosterone effects on salt homeostasis and blood pressure regulation. MR activation also promotes inflammation, cardiovascular remodelling and endothelial dysfunction, and affects adipose tissue differentiation and function. Some of these effects derive from MR activation by glucocorticoids. Recent epidemiological studies show that the incidence of metabolic syndrome increases across quartiles of aldosterone, implicating the MR as a central player in metabolic homeostasis, involving electrolyte, water and energy balance. This review summarizes the current understanding of MR-mediated effects in diverse tissues and the role of aldosterone as a cardiometabolic risk factor, and discusses the possible relationship between inappropriate MR activation (by both mineralocorticoids and glucocorticoids) and the development of metabolic syndrome.
UR - http://www.scopus.com/inward/record.url?scp=72149099639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72149099639&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2009.05.006
DO - 10.1016/j.tem.2009.05.006
M3 - Article
C2 - 19800255
AN - SCOPUS:72149099639
VL - 20
SP - 444
EP - 451
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 9
ER -