Mini-mental state examination in Alzheimer's disease and multi-infarct dementia

Eugenio Magni, Giuliano Binetti, Alessandro Padovani, Stefano F. Cappa, Angelo Bianchetti, Marco Trabucchi

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalInternational Psychogeriatrics
Volume8
Issue number1
DOIs
Publication statusPublished - Mar 1996

Fingerprint

Multi-Infarct Dementia
Alzheimer Disease
Education
Episodic Memory
Principal Component Analysis
Statistical Factor Analysis
Motivation
Analysis of Variance
Depression

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Ageing
  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Mini-mental state examination in Alzheimer's disease and multi-infarct dementia. / Magni, Eugenio; Binetti, Giuliano; Padovani, Alessandro; Cappa, Stefano F.; Bianchetti, Angelo; Trabucchi, Marco.

In: International Psychogeriatrics, Vol. 8, No. 1, 03.1996, p. 127-134.

Research output: Contribution to journalArticle

Magni, Eugenio ; Binetti, Giuliano ; Padovani, Alessandro ; Cappa, Stefano F. ; Bianchetti, Angelo ; Trabucchi, Marco. / Mini-mental state examination in Alzheimer's disease and multi-infarct dementia. In: International Psychogeriatrics. 1996 ; Vol. 8, No. 1. pp. 127-134.
@article{623edb991f62421d92918c5af5883974,
title = "Mini-mental state examination in Alzheimer's disease and multi-infarct dementia",
abstract = "The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.",
author = "Eugenio Magni and Giuliano Binetti and Alessandro Padovani and Cappa, {Stefano F.} and Angelo Bianchetti and Marco Trabucchi",
year = "1996",
month = "3",
doi = "10.1017/S1041610296002529",
language = "English",
volume = "8",
pages = "127--134",
journal = "International Psychogeriatrics",
issn = "1041-6102",
publisher = "Cambridge University Press",
number = "1",

}

TY - JOUR

T1 - Mini-mental state examination in Alzheimer's disease and multi-infarct dementia

AU - Magni, Eugenio

AU - Binetti, Giuliano

AU - Padovani, Alessandro

AU - Cappa, Stefano F.

AU - Bianchetti, Angelo

AU - Trabucchi, Marco

PY - 1996/3

Y1 - 1996/3

N2 - The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.

AB - The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.

UR - http://www.scopus.com/inward/record.url?scp=0029977176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029977176&partnerID=8YFLogxK

U2 - 10.1017/S1041610296002529

DO - 10.1017/S1041610296002529

M3 - Article

C2 - 8805093

AN - SCOPUS:0029977176

VL - 8

SP - 127

EP - 134

JO - International Psychogeriatrics

JF - International Psychogeriatrics

SN - 1041-6102

IS - 1

ER -