Abstract
The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.
| Original language | English |
|---|---|
| Pages (from-to) | 127-134 |
| Number of pages | 8 |
| Journal | International Psychogeriatrics |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 1996 |
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ASJC Scopus subject areas
- Geriatrics and Gerontology
- Ageing
- Psychiatry and Mental health
- Psychology(all)
- Clinical Psychology
Cite this
Mini-mental state examination in Alzheimer's disease and multi-infarct dementia. / Magni, Eugenio; Binetti, Giuliano; Padovani, Alessandro; Cappa, Stefano F.; Bianchetti, Angelo; Trabucchi, Marco.
In: International Psychogeriatrics, Vol. 8, No. 1, 03.1996, p. 127-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mini-mental state examination in Alzheimer's disease and multi-infarct dementia
AU - Magni, Eugenio
AU - Binetti, Giuliano
AU - Padovani, Alessandro
AU - Cappa, Stefano F.
AU - Bianchetti, Angelo
AU - Trabucchi, Marco
PY - 1996/3
Y1 - 1996/3
N2 - The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.
AB - The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.
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U2 - 10.1017/S1041610296002529
DO - 10.1017/S1041610296002529
M3 - Article
VL - 8
SP - 127
EP - 134
JO - International Psychogeriatrics
JF - International Psychogeriatrics
SN - 1041-6102
IS - 1
ER -