Mini Review Immunological Consequences of Immunization With COVID-19 mRNA Vaccines: Preliminary Results

Andrea Lombardi, Giorgio Bozzi, Riccardo Ungaro, Simone Villa, Valeria Castelli, Davide Mangioni, Antonio Muscatello, Andrea Gori, Alessandra Bandera

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: BNT162b2 and mRNA-1273 are the two recently approved mRNA-based vaccines against COVID-19 which has shown excellent safety and efficacy. Preliminary data about specific and neutralizing antibodies is available covering the first 100 days after vaccination. Methods: We reviewed all the publications regarding the immunologic consequences of BNT162b2 and mRNA-1273 vaccination. A summary of specific antibodies concentration and neutralizing antibodies titers elicited by each vaccine is provided. Results: BNT162b2 and mRNA-1273 displayed a reassuring safety and efficacy profile, with the latter above 94%. They can elicit specific antibodies titers and neutralizing antibodies concentrations that are far superior from those observed among COVID-19 human convalescent serum, across a wide span of age, for at least 100 days after vaccination. Moreover, the vaccine-induced T cellular response is oriented toward a TH1 response and no evidence of vaccine-enhanced disease have been reported. Discussion: BNT162b2 and mRNA-1273 can elicit specific antibodies titers and neutralizing antibodies concentrations above those observed among COVID-19 human convalescent serum in the first 100 days after vaccination. Data about vaccine efficacy in those with previous COVID-19 or immunocompromised is still limited.

Original languageEnglish
Article number657711
JournalFrontiers in Immunology
Volume12
DOIs
Publication statusPublished - Mar 12 2021

Keywords

  • antibodies
  • COVID-19
  • CTL
  • neutralization test
  • RNA vaccine
  • SARS-CoV-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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