Abstract
Despite central nervous system (CNS) prophylactic programs limit leptomeningeal involvement in acute lymphoblastic leukemia (ALL), it can still occur in a restricted percentage of cases. The exact risk rate remains still unknown, and several factors are associated with an increased probability to develop CNS involvement. Among them, Philadelphia (Ph)-positive genotype seems to play a relevant role. Recently, a flow cytometric assay to detect BCR-ABL protein has been developed, but little is known about its possible employment in leptomeningeal disease. Here, we show the miniaturized application of the original assay for BCR-ABL oncoprotein detection in cerebrospinal fluid (CSF) samples.
Original language | English |
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Pages (from-to) | 1290-1293 |
Number of pages | 4 |
Journal | Leukemia Research |
Volume | 35 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2011 |
Keywords
- BCR-ABL oncoprotein
- Cerebrospinal fluid
- Flow cytometry
- Immunobead assay
- Philadelphia-positive leukemia
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology