Abstract
The intravenous glucose tolerance test (IVGTT) single-compartment minimal model (1CMM) method has recently been shown to overestimate glucose effectiveness and underestimate insulin sensitivity. Undermodeling, i.e., use of single- instead of two-compartment description of glucose kinetics, has been advocated to explain these limitations. We describe a new two- compartment minimal model (2CMM) into which we incorporate certain available knowledge on glucose kinetics. 2CMM is numerically identified using a Bayesian approach. Twenty-two standard IVGTT (0.30 g/kg) in normal humans were analyzed. In six subjects, the clamp-based index of insulin sensitivity (S(I)/(c)) was also measured. 2CMM glucose effectiveness (S(G)/2) and insulin sensitivity (S(I)/2) were, respectively, 60% lower (P <0.0001) and 35% higher (P <0.0001) than the corresponding 1CMM S(G)/1 and S(I)/1 indexes: 2.81 ± 0.29 (SE) vs. S(G)/1 = 4.27 ± 0.33 ml·min-1·kg-1 and S(I)/2 = 11.67 ± 1.71 vs. S(I)/1 = 8.68 ± 1.62 102 ml·min-1·kg-1 per μU/ml. S(I)/2 was not different from S(I)/(c) = 12.61 ± 2.13 102 ml·min-1·kg-1 per μU/ml (nonsignificant), whereas S(I)/1 was 60% lower (P <0.02). In conclusion, a new 2CMM has been presented that improves the accuracy of glucose effectiveness and insulin sensitivity estimates of the classic 1CMM from a standard IVGTT in normal humans.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Endocrinology and Metabolism |
| Volume | 277 |
| Issue number | 3 40-3 |
| Publication status | Published - Sep 1999 |
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Keywords
- Glucose clamp technique
- Glucose effectiveness
- Glucose kinetics
- Insulin sensitivity
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Physiology (medical)
Cite this
Minimal model S(G) overestimation and S(I) underestimation : Improved accuracy by a Bayesian two-compartment model. / Cobelli, Claudio; Caumo, Andrea; Omenetto, Matteo.
In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 277, No. 3 40-3, 09.1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Minimal model S(G) overestimation and S(I) underestimation
T2 - Improved accuracy by a Bayesian two-compartment model
AU - Cobelli, Claudio
AU - Caumo, Andrea
AU - Omenetto, Matteo
PY - 1999/9
Y1 - 1999/9
N2 - The intravenous glucose tolerance test (IVGTT) single-compartment minimal model (1CMM) method has recently been shown to overestimate glucose effectiveness and underestimate insulin sensitivity. Undermodeling, i.e., use of single- instead of two-compartment description of glucose kinetics, has been advocated to explain these limitations. We describe a new two- compartment minimal model (2CMM) into which we incorporate certain available knowledge on glucose kinetics. 2CMM is numerically identified using a Bayesian approach. Twenty-two standard IVGTT (0.30 g/kg) in normal humans were analyzed. In six subjects, the clamp-based index of insulin sensitivity (S(I)/(c)) was also measured. 2CMM glucose effectiveness (S(G)/2) and insulin sensitivity (S(I)/2) were, respectively, 60% lower (P <0.0001) and 35% higher (P <0.0001) than the corresponding 1CMM S(G)/1 and S(I)/1 indexes: 2.81 ± 0.29 (SE) vs. S(G)/1 = 4.27 ± 0.33 ml·min-1·kg-1 and S(I)/2 = 11.67 ± 1.71 vs. S(I)/1 = 8.68 ± 1.62 102 ml·min-1·kg-1 per μU/ml. S(I)/2 was not different from S(I)/(c) = 12.61 ± 2.13 102 ml·min-1·kg-1 per μU/ml (nonsignificant), whereas S(I)/1 was 60% lower (P <0.02). In conclusion, a new 2CMM has been presented that improves the accuracy of glucose effectiveness and insulin sensitivity estimates of the classic 1CMM from a standard IVGTT in normal humans.
AB - The intravenous glucose tolerance test (IVGTT) single-compartment minimal model (1CMM) method has recently been shown to overestimate glucose effectiveness and underestimate insulin sensitivity. Undermodeling, i.e., use of single- instead of two-compartment description of glucose kinetics, has been advocated to explain these limitations. We describe a new two- compartment minimal model (2CMM) into which we incorporate certain available knowledge on glucose kinetics. 2CMM is numerically identified using a Bayesian approach. Twenty-two standard IVGTT (0.30 g/kg) in normal humans were analyzed. In six subjects, the clamp-based index of insulin sensitivity (S(I)/(c)) was also measured. 2CMM glucose effectiveness (S(G)/2) and insulin sensitivity (S(I)/2) were, respectively, 60% lower (P <0.0001) and 35% higher (P <0.0001) than the corresponding 1CMM S(G)/1 and S(I)/1 indexes: 2.81 ± 0.29 (SE) vs. S(G)/1 = 4.27 ± 0.33 ml·min-1·kg-1 and S(I)/2 = 11.67 ± 1.71 vs. S(I)/1 = 8.68 ± 1.62 102 ml·min-1·kg-1 per μU/ml. S(I)/2 was not different from S(I)/(c) = 12.61 ± 2.13 102 ml·min-1·kg-1 per μU/ml (nonsignificant), whereas S(I)/1 was 60% lower (P <0.02). In conclusion, a new 2CMM has been presented that improves the accuracy of glucose effectiveness and insulin sensitivity estimates of the classic 1CMM from a standard IVGTT in normal humans.
KW - Glucose clamp technique
KW - Glucose effectiveness
KW - Glucose kinetics
KW - Insulin sensitivity
UR - http://www.scopus.com/inward/record.url?scp=0033194665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033194665&partnerID=8YFLogxK
M3 - Article
VL - 277
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 3 40-3
ER -