Minimal models in meal-like protocols: Simulation studies to assess precision and physiological plausibility of parameter estimates

F. Bettini, A. Caumo, C. Cobelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the present study we evaluated the impact of different experimental protocols on glucose minimal models identification. We used a realistic comprehensive nonlinear model of the glucose-insulin system to generate unlabeled and labeled glucose data during an IVGTT and a meal-like study. Subsequently, Monte Carlo simulations were used to compare the values and precision of the estimates of the minimal models indices obtained from the two experimental protocols. Our results demonstrate that both the values and the precision of the minimal model parameters are influenced by the experimental protocol. In particular, we found that the minimal model parameters estimated from the meal-like study are less precise but probably more physiologically plausible than those obtained from the IVGTT. The lower precision achieved with the meal-like study protocol is probably due to both the relatively unfrequent sampling schedule and the non-optimality of the glucose and insulin profiles for minimal model analysis.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Editors Anon
Pages1361-1362
Number of pages2
Volume17
Edition2
Publication statusPublished - 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

Other

OtherProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)
CityMontreal, Can
Period9/20/959/23/95

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Bettini, F., Caumo, A., & Cobelli, C. (1995). Minimal models in meal-like protocols: Simulation studies to assess precision and physiological plausibility of parameter estimates. In Anon (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (2 ed., Vol. 17, pp. 1361-1362)