Minimal Residual Disease in Acute Myeloid Leukemia of Adults: Determination, Prognostic Impact and Clinical Applications

Maria Ilaria Del Principe, Francesco Buccisano, Luca Maurillo, Giuseppe Sconocchia, Mariagiovanna Cefalo, Maria Irno Consalvo, Chiara Sarlo, Consuelo Conti, Giovanna De Santis, Eleonora De Bellis, Ambra Di Veroli, Patrizia Palomba, Cristina Attrotto, Annagiulia Zizzari, Giovangiacinto Paterno, Maria Teresa Voso, Giovanni Del Poeta, Francesco Lo-Coco, William Arcese, Sergio AmadoriAdriano Venditti

Research output: Contribution to journalArticle

Abstract

Pretreatment assessment of cytogenetic/genetic signature of acute myeloid leukemia (AML) has been consistently shown to play a major prognostic role but also to fail at predicting outcome on individual basis, even in low-risk AML. Therefore, we are in need of further accurate methods to refine the patients' risk allocation process, distinguishing more adequately those who are likely to recur from those who are not. In this view, there is now evidence that the submicroscopic amounts of leukemic cells (called minimal residual disease, MRD), measured during the course of treatment, indicate the quality of response to therapy. Therefore, MRD might serve as an independent, additional biomarker to help to identify patients at higher risk of relapse. Detection of MRD requires the use of highly sensitive ancillary techniques, such as polymerase chain reaction (PCR) and multiparametric flow cytometry(MPFC). In the present manuscript, we will review the current approaches to investigate MRD and its clinical applications in AML management.

Original languageEnglish
Pages (from-to)e2016052
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume8
Issue number1
DOIs
Publication statusPublished - 2016

Keywords

  • Review
  • Journal Article

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    Del Principe, M. I., Buccisano, F., Maurillo, L., Sconocchia, G., Cefalo, M., Consalvo, M. I., Sarlo, C., Conti, C., De Santis, G., De Bellis, E., Veroli, A. D., Palomba, P., Attrotto, C., Zizzari, A., Paterno, G., Voso, M. T., Del Poeta, G., Lo-Coco, F., Arcese, W., ... Venditti, A. (2016). Minimal Residual Disease in Acute Myeloid Leukemia of Adults: Determination, Prognostic Impact and Clinical Applications. Mediterranean Journal of Hematology and Infectious Diseases, 8(1), e2016052. https://doi.org/10.4084/MJHID.2016.052