Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies

Phillip Lord, Rachel Spiering, Juan C. Aguillon, Amy E. Anderson, Silke Appel, Daniel Benitez-Ribas, Anja ten Brinke, Femke Broere, Nathalie Cools, Maria Cristina Cuturi, Julie Diboll, Edward K. Geissler, Nick Giannoukakis, Silvia Gregori, S. Marieke van Ham, Staci Lattimer, Lindsay Marshall, Rachel A. Harry, James A. Hutchinson, John D. IsaacsIrma Joosten, Cees van Kooten, Ascension Lopez Diaz de Cerio, Tatjana Nikolic, Haluk Barbaros Oral, Ljiljana Sofronic-Milosavljevic, Thomas Ritter, Paloma Riquelme, Angus W. Thomson, Massimo Trucco, Marta Vives-Pi, Eva M. Martinez-Caceres, Catharien M U Hilkens

Research output: Contribution to journalArticle

Abstract

Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.

Original languageEnglish
Article numbere2300
JournalPeerJ
Volume2016
Issue number8
DOIs
Publication statusPublished - 2016

Keywords

  • Antigen-presenting cells
  • Autoimmune disease
  • Cell therapy
  • Minimum information model
  • Regulatory macrophages
  • Reporting guidelines
  • Tolerogenic dendritic cells
  • Transplantation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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  • Cite this

    Lord, P., Spiering, R., Aguillon, J. C., Anderson, A. E., Appel, S., Benitez-Ribas, D., ten Brinke, A., Broere, F., Cools, N., Cuturi, M. C., Diboll, J., Geissler, E. K., Giannoukakis, N., Gregori, S., Marieke van Ham, S., Lattimer, S., Marshall, L., Harry, R. A., Hutchinson, J. A., ... Hilkens, C. M. U. (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. PeerJ, 2016(8), [e2300]. https://doi.org/10.7717/peerj.2300