Mininvasive treatment with collagen of female urinary incontinence

E. Pisani, F. Mantovani, G. Zanetti, A. Ceresoli, M. Seveso

Research output: Contribution to journalArticlepeer-review


Cross linked collagen in gluteraldehyde solution (GAX Collagen) was recently available for clinical use. We have been using Contigen Bard by intraurethral injection in selected patients for the last 2 years. N 12 patients (age range 52-68) were evaluated and injected. Previous operations (1-3) had failed in 6 pts. We performed intraurethral injections of 2,5 to 5 ml of contigen by means of only two implants at points 3 and 9 o'clock of bladder neck. N 8 patients were cured (2 injected twice) and 4 improved. The follow up is of 12 months and no decrease of effectiveness was observed. Gax Collagen can be injected intraurethrally to treat incontinence. On medium term follow up is well tolerated by the host tissue, easily injectable due to its low viscosity. The implant is progressively colonized by the host collagen and vessels with low immunogenicity. The treatment is performed in cystosuite in 15 minutes without anesthesia: nothing else is comparable in cost/benefit ratio.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalUrogynaecologia International Journal
Issue number2
Publication statusPublished - 1995


  • collagen
  • incontinence
  • transurethral injection

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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