MiR-146a is modulated in human endothelial cell with aging

Mariuca Vasa-Nicotera, Hailan Chen, Paola Tucci, Ai Li Yang, Gaelle Saintigny, Rossella Menghini, Christian Mahè, Massimiliano Agostini, Richard A. Knight, Gerry Melino, Massimo Federici

Research output: Contribution to journalArticle

Abstract

Background: Increasing evidence has demonstrated that the senescence of vascular endothelial cells has critical roles in the pathogenesis of vascular dysfunction such as atherosclerosis and thrombosis. MicroRNA (miR) are small non-coding RNAs that inhibit gene expression by binding to complementary sequences in the 3'UTR of their target mRNAs. MiRs modulate a variety of biological functions such as cell development, cell differentiation, and apoptosis. Moreover, several miRs involved in endothelial cell function have been identified. Methods and results: Through a microarray approach, we have identified a miR-146a that is progressively modulated in endothelial cells with aging. In young human umbilical vein endothelial cells, this miR is involved in a premature senescence-like phenotype through direct targeting of the NOX4 protein, implicated in cell senescence and aging. Conclusions and general significance: Finding important factors that regulate endothelial cell senescence, like miR-146a, will help provide novel therapeutic strategies for vascular disorders.

Original languageEnglish
Pages (from-to)326-330
Number of pages5
JournalAtherosclerosis
Volume217
Issue number2
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Apoptosis
  • Cell death
  • Endothelial cells
  • Microarray
  • MicroRna
  • Senescence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Vasa-Nicotera, M., Chen, H., Tucci, P., Yang, A. L., Saintigny, G., Menghini, R., Mahè, C., Agostini, M., Knight, R. A., Melino, G., & Federici, M. (2011). MiR-146a is modulated in human endothelial cell with aging. Atherosclerosis, 217(2), 326-330. https://doi.org/10.1016/j.atherosclerosis.2011.03.034