@article{ff6a8fb60b9e4d999d3bef018e39ec7c,
title = "miR-146a Plasma Levels Are Not Altered in Alzheimer{\textquoteright}s Disease but Correlate With Age and Illness Severity: Frontiers in Aging Neuroscience",
abstract = "miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer{\textquoteright}s disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plasma from 33 AD patients vs. 28 age-matched non-affected controls (CTRL) through quantitative real-time polymerase chain reaction (qRT-PCR). No difference between the case and the control group was evidenced, but a correlation was detected between miR-146a levels and subjects{\textquoteright} age (p <0.001) as well as between miR-146a levels and patients{\textquoteright} Mini-Mental State Examination (MMSE) scores (p = 0.011), in an enlarged group of 51 AD patients and 45 CTRL supporting a role for this miRNA in aging processes and disease progression. {\textcopyright} Copyright {\textcopyright} 2020 Maffioletti, Milanesi, Ansari, Zanetti, Galluzzi, Geroldi, Gennarelli and Bocchio-Chiavetto.",
keywords = "aging, Alzheimer{\textquoteright}s disease, blood, microRNA, miR-146a, plasma, microRNA 146a, aged, Alzheimer disease, Article, blood level, controlled study, disease association, disease exacerbation, disease severity, female, human, major clinical study, male, Mini Mental State Examination, real time polymerase chain reaction, risk factor",
author = "E. Maffioletti and E. Milanesi and A. Ansari and O. Zanetti and S. Galluzzi and C. Geroldi and M. Gennarelli and L. Bocchio-Chiavetto",
note = "Cited By :4 Export Date: 11 February 2021 Correspondence Address: Gennarelli, M.; Genetics Unit, Italy; email: massimo.gennarelli@unibs.it Funding details: European Regional Development Fund, FEDER, P_37_732/2016 REDBRAIN Funding details: RF-2013-02356444 Funding text 1: Funding. This research was funded by the Italian Ministry of Health (Ricerca Corrente) and Ricerca Finalizzata 2013 (Grant: RF-2013-02356444). EMi is recipient of a contract of the European Regional Development Fund, Competitiveness Operational Program 2014-2020, through the grant P_37_732/2016 REDBRAIN. References: Ansari, A., Maffioletti, E., Milanesi, E., Marizzoni, M., Frisoni, G.B., Blin, O., miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer{\textquoteright}s disease (2019) Neurobiol. Aging, 82, pp. 102-109. , 31437718; Bae, S.C., Lee, Y.H., MiR-146a levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis (2018) Int. J. Rheum. Dis, 21, pp. 1335-1342. , 29968332; Batistela, M.S., Josviak, N.D., Sulzbach, C.D., de Souza, R.L., An overview of circulating cell-free microRNAs as putative biomarkers in Alzheimer{\textquoteright}s and Parkinson{\textquoteright}s diseases (2017) Int. J. Neurosci, 127, pp. 547-558. , 27381850; Deng, S., Wang, H., Jia, C., Zhu, S., Chu, X., Ma, Q., MicroRNA-146a induces lineage-negative bone marrow cell apoptosis and senescence by targeting polo-like kinase 2 expression (2017) Arterioscler. Thromb. Vasc. Biol, 37, pp. 280-290. , 27908889; Denk, J., Boelmans, K., Siegismund, C., Lassner, D., Arlt, S., Jahn, H., MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer{\textquoteright}s disease (2015) PLoS One, 10, p. e0126423. , 25992776; Dong, H., Li, J., Huang, L., Chen, X., Li, D., Wang, T., Serum microRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer{\textquoteright}s disease (2015) Dis. Markers, 2015, p. 625659. , 26078483; Frisoni, G.B., Prestia, A., Zanetti, O., Galluzzi, S., Romano, M., Cotelli, M., Markers of Alzheimer{\textquoteright}s disease in a population attending a memory clinic (2009) Alzheimers Dement, 5, pp. 307-317. , 19560101; Jiang, M., Xiang, Y., Wang, D., Gao, J., Liu, D., Liu, Y., Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages (2012) Aging Cell, 11, pp. 29-40. , 21981419; Jurkin, J., Schichl, Y.M., Koeffel, R., Bauer, T., Richter, S., Konradi, S., miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation (2010) J. Immunol, 184, pp. 4955-4965. , 20375304; Kiko, T., Nakagawa, K., Tsuduki, T., Furukawa, K., Arai, H., Miyazawa, T., MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer{\textquoteright}s disease (2014) J. Alzheimers Dis, 39, pp. 253-259. , 24157723; Maffioletti, E., Tardito, D., Gennarelli, M., Bocchio Chiavetto, L., Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders (2014) Front. Cell. Neurosci, 8, p. 75. , 24653674; McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer{\textquoteright}s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer{\textquoteright}s disease (1984) Neurology, 34, pp. 939-944. , 6610841; Meerson, A., Najjar, A., Saad, E., Sbeit, W., Barhoum, M., Assy, N., Sex differences in plasma microRNA biomarkers of early and complicated diabetes mellitus in Israeli Arab and Jewish patients (2019) Noncoding RNA, 5, p. E32. , 30959814; M{\"u}ller, M., Kuiperij, H.B., Claassen, J.A., K{\"u}sters, B., Verbeek, M.M., MicroRNAs in Alzheimer{\textquoteright}s disease: differential expression in hippocampus and cell-free cerebrospinal fluid (2014) Neurobiol. Aging, 35, pp. 152-158. , 23962497; M{\"u}ller, M., Kuiperij, H.B., Versleijen, A.A., Chiasserini, D., Farotti, L., Baschieri, F., Validation of microRNAs in cerebrospinal fluid as biomarkers for different forms of dementia in a multicenter study (2016) J. Alzheimers Dis, 52, pp. 1321-1333. , 27104900; O{\textquoteright}Carroll, D., Schaefer, A., General principals of miRNA biogenesis and regulation in the brain (2013) Neuropsychopharmacology, 38, pp. 39-54. , 22669168; Reddy, P.H., Tonk, S., Kumar, S., Vijayan, M., Kandimalla, R., Kuruva, C.S., A critical evaluation of neuroprotective and neurodegenerative microRNAs in Alzheimer{\textquoteright}s disease (2017) Biochem. Biophys. Res. Commun, 483, pp. 1156-1165. , 27524239; Zheng, L., Zhuang, C., Wang, X., Ming, L., Serum miR-146a, miR-155, and miR-210 as potential markers of Graves{\textquoteright} disease (2018) J. Clin. Lab. Anal, 32, p. e22266. , 28569050",
year = "2020",
doi = "10.3389/fnagi.2019.00366",
language = "English",
volume = "11",
journal = "Front. Aging Neurosci.",
issn = "1663-4365",
publisher = "Frontiers Media S.A.",
}