miR-146a Plasma Levels Are Not Altered in Alzheimer’s Disease but Correlate With Age and Illness Severity: Frontiers in Aging Neuroscience

E. Maffioletti, E. Milanesi, A. Ansari, O. Zanetti, S. Galluzzi, C. Geroldi, M. Gennarelli, L. Bocchio-Chiavetto

Research output: Contribution to journalArticlepeer-review

Abstract

miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer’s disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plasma from 33 AD patients vs. 28 age-matched non-affected controls (CTRL) through quantitative real-time polymerase chain reaction (qRT-PCR). No difference between the case and the control group was evidenced, but a correlation was detected between miR-146a levels and subjects’ age (p <0.001) as well as between miR-146a levels and patients’ Mini-Mental State Examination (MMSE) scores (p = 0.011), in an enlarged group of 51 AD patients and 45 CTRL supporting a role for this miRNA in aging processes and disease progression. © Copyright © 2020 Maffioletti, Milanesi, Ansari, Zanetti, Galluzzi, Geroldi, Gennarelli and Bocchio-Chiavetto.
Original languageEnglish
Article number366
JournalFront. Aging Neurosci.
Volume11
DOIs
Publication statusPublished - 2020

Keywords

  • aging
  • Alzheimer’s disease
  • blood
  • microRNA
  • miR-146a
  • plasma
  • microRNA 146a
  • aged
  • Alzheimer disease
  • Article
  • blood level
  • controlled study
  • disease association
  • disease exacerbation
  • disease severity
  • female
  • human
  • major clinical study
  • male
  • Mini Mental State Examination
  • real time polymerase chain reaction
  • risk factor

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