MiR-205 expression levels in nonsmall cell lung cancerdo not always distinguish adenocarcinomas from squamous cell carcinomas

Valerio Del Vescovo, Chiara Cantaloni, Alberto Cucino, Salvatore Girlando, Massimo Silvestri, Emma Bragantini, Silvia Fasanella, Lucia Veronica Cuorvo, Paolo Dalla Palma, Giulio Rossi, Mauro Papotti, Giuseppe Pelosi, Paolo Graziano, Alberto Cavazza, Michela Alessandra Denti, Mattia Barbareschi

Research output: Contribution to journalArticle

Abstract

Accurate classification of nonsmall cell lung cancers is of paramount clinical relevance, as novel chemotherapeutic agents show different efficacy in adenocarcinomas (ADCs) compared with squamous cell carcinomas (SQCCs). Cyto and histomorphology may sometimes be insufficient for this distinction and immunohistochemistry may improve diagnostic accuracy. The measurement of miR-205 may be another tool for the distinction between ADC and SQCC. The aim of our study was to compare morphologic and immunohistochemical classification with the relative quantification of miR-205 and miR-21 insurgically resected and well-characterized lung tumors (25 ADCs, 24 SQCCs, 1 adenosquamous). The miR-21 relative levels were similar in SQCC and ADC, whereas the miR-205 relative levels were lower in ADC (P

Original languageEnglish
Pages (from-to)268-275
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • classification
  • lung cancer
  • microRNA
  • miR 205
  • target therapy

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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  • Cite this

    Vescovo, V. D., Cantaloni, C., Cucino, A., Girlando, S., Silvestri, M., Bragantini, E., Fasanella, S., Cuorvo, L. V., Palma, P. D., Rossi, G., Papotti, M., Pelosi, G., Graziano, P., Cavazza, A., Denti, M. A., & Barbareschi, M. (2011). MiR-205 expression levels in nonsmall cell lung cancerdo not always distinguish adenocarcinomas from squamous cell carcinomas. American Journal of Surgical Pathology, 35(2), 268-275. https://doi.org/10.1097/PAS.0b013e3182068171