miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA

Valeria Valsecchi, Serenella Anzilotti, Angelo Serani, Giusy Laudati, Paola Brancaccio, Natascia Guida, Ornella Cuomo, Giuseppe Pignataro, Lucio Annunziato

Research output: Contribution to journalArticlepeer-review

Abstract

Motor neuron degeneration occurs very early in the facial nuclei of SMA mice, paralleling a transient upregulation of miR-206. The prolonged increase of miR-206 induced by i.c.v. administration reduces motor neuron loss, ameliorates behavioral performance, and increases mouse lifespan, also through the modulation of the plasma membrane Na+/Ca2+ exchanger 2, NCX2.

Original languageEnglish
Pages (from-to)1154-1166
Number of pages13
JournalMolecular Therapy
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 8 2020

Keywords

  • Brainstem
  • miR-206
  • motor neuron disease
  • NCX2
  • spinal muscular atrophy

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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