miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA

Valeria Valsecchi; Serenella Anzilotti; Angelo Serani; Giusy Laudati; Paola Brancaccio; Natascia Guida; Ornella Cuomo; Giuseppe Pignataro; Lucio Annunziato

doi:10.1016/j.ymthe.2020.01.013

miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA

Valeria Valsecchi, Serenella Anzilotti, Angelo Serani, Giusy Laudati, Paola Brancaccio, Natascia Guida, Ornella Cuomo, Giuseppe Pignataro, Lucio Annunziato

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

Motor neuron degeneration occurs very early in the facial nuclei of SMA mice, paralleling a transient upregulation of miR-206. The prolonged increase of miR-206 induced by i.c.v. administration reduces motor neuron loss, ameliorates behavioral performance, and increases mouse lifespan, also through the modulation of the plasma membrane Na⁺/Ca²⁺ exchanger 2, NCX2.

Original language	English
Pages (from-to)	1154-1166
Number of pages	13
Journal	Molecular Therapy
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.ymthe.2020.01.013
Publication status	Published - Apr 8 2020

Keywords

Brainstem
miR-206
motor neuron disease
NCX2
spinal muscular atrophy

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

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miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA. / Valsecchi, Valeria; Anzilotti, Serenella; Serani, Angelo; Laudati, Giusy; Brancaccio, Paola; Guida, Natascia; Cuomo, Ornella; Pignataro, Giuseppe; Annunziato, Lucio.

In: Molecular Therapy, Vol. 28, No. 4, 08.04.2020, p. 1154-1166.

Research output: Contribution to journal › Article › peer-review

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abstract = "Motor neuron degeneration occurs very early in the facial nuclei of SMA mice, paralleling a transient upregulation of miR-206. The prolonged increase of miR-206 induced by i.c.v. administration reduces motor neuron loss, ameliorates behavioral performance, and increases mouse lifespan, also through the modulation of the plasma membrane Na+/Ca2+ exchanger 2, NCX2.",

keywords = "Brainstem, miR-206, motor neuron disease, NCX2, spinal muscular atrophy",

author = "Valeria Valsecchi and Serenella Anzilotti and Angelo Serani and Giusy Laudati and Paola Brancaccio and Natascia Guida and Ornella Cuomo and Giuseppe Pignataro and Lucio Annunziato",

note = "Funding Information: This work was supported by the following grants: Programma Operativo Nazionale ( PON_01602 and PON03PE_00146_1 ) from MIUR to L.A.; PRIN 2015 2015783N45-CUP: E62F1600136001 to G.P.; and the Italian Ministry of Economic Development (MISE), Nanomirnictus, F/050139/01,02/X32 to L.A. Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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AU - Serani, Angelo

AU - Laudati, Giusy

AU - Brancaccio, Paola

AU - Guida, Natascia

AU - Cuomo, Ornella

AU - Pignataro, Giuseppe

AU - Annunziato, Lucio

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