@article{fb6cbc0064da447abbd4931d6879ec27,
title = "miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA",
abstract = "Motor neuron degeneration occurs very early in the facial nuclei of SMA mice, paralleling a transient upregulation of miR-206. The prolonged increase of miR-206 induced by i.c.v. administration reduces motor neuron loss, ameliorates behavioral performance, and increases mouse lifespan, also through the modulation of the plasma membrane Na+/Ca2+ exchanger 2, NCX2.",
keywords = "Brainstem, miR-206, motor neuron disease, NCX2, spinal muscular atrophy",
author = "Valeria Valsecchi and Serenella Anzilotti and Angelo Serani and Giusy Laudati and Paola Brancaccio and Natascia Guida and Ornella Cuomo and Giuseppe Pignataro and Lucio Annunziato",
note = "Funding Information: This work was supported by the following grants: Programma Operativo Nazionale ( PON_01602 and PON03PE_00146_1 ) from MIUR to L.A.; PRIN 2015 2015783N45-CUP: E62F1600136001 to G.P.; and the Italian Ministry of Economic Development (MISE), Nanomirnictus, F/050139/01,02/X32 to L.A. Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = apr,
day = "8",
doi = "10.1016/j.ymthe.2020.01.013",
language = "English",
volume = "28",
pages = "1154--1166",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Nature Publishing Group",
number = "4",
}