MiR-21 is overexpressed in NPM1-mutant acute myeloid leukemias

Roberta Riccioni, Valentina Lulli, Germana Castelli, Mauro Biffoni, Rosella Tiberio, Elvira Pelosi, Francesco Lo-Coco, Ugo Testa

Research output: Contribution to journalArticlepeer-review

Abstract

miR-21 is dysregulated in several types of cancers, including some hematologic malignancies, and plays a key role in carcinogenesis, disease recurrence and metastasis. However, no studies have specifically investigated the role of miR-21 in AMLs. In this study we analyzed the expression of miR-21 and of its target PDCD4 (Programmed Cell Death 4) during normal hematopoietic differentiation and in AMLs. Our results showed that: (i) miR-21 expression is strongly up-modulated during normal granulo/monocytic differentiation, while PDCD4 protein level is concomitantly downmodulated; (ii) miR-21 is frequently overexpressed in AML blasts, in association with a marked PDCD4 protein downmodulation; (iii) miR-21 expression level is particularly elevated in NPM1mutant AMLs. Together, these findings suggest that deregulated miR-21 expression may contribute to disease pathogenesis in NPM1-mutated AMLs.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalLeukemia Research
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Acute myeloid leukemia
  • Cell differentiation
  • Leukemia
  • Membrane antigens
  • MicroRNA

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology
  • Medicine(all)

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