MiR-21 is overexpressed in NPM1-mutant acute myeloid leukemias

Roberta Riccioni, Valentina Lulli, Germana Castelli, Mauro Biffoni, Rosella Tiberio, Elvira Pelosi, Francesco Lo-Coco, Ugo Testa

Research output: Contribution to journalArticle

Abstract

miR-21 is dysregulated in several types of cancers, including some hematologic malignancies, and plays a key role in carcinogenesis, disease recurrence and metastasis. However, no studies have specifically investigated the role of miR-21 in AMLs. In this study we analyzed the expression of miR-21 and of its target PDCD4 (Programmed Cell Death 4) during normal hematopoietic differentiation and in AMLs. Our results showed that: (i) miR-21 expression is strongly up-modulated during normal granulo/monocytic differentiation, while PDCD4 protein level is concomitantly downmodulated; (ii) miR-21 is frequently overexpressed in AML blasts, in association with a marked PDCD4 protein downmodulation; (iii) miR-21 expression level is particularly elevated in NPM1mutant AMLs. Together, these findings suggest that deregulated miR-21 expression may contribute to disease pathogenesis in NPM1-mutated AMLs.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalLeukemia Research
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

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Apoptosis Regulatory Proteins
Acute Myeloid Leukemia
Hematologic Neoplasms
Carcinogenesis
Cell Death
Neoplasm Metastasis
Recurrence
Neoplasms

Keywords

  • Acute myeloid leukemia
  • Cell differentiation
  • Leukemia
  • Membrane antigens
  • MicroRNA

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology
  • Medicine(all)

Cite this

Riccioni, R., Lulli, V., Castelli, G., Biffoni, M., Tiberio, R., Pelosi, E., ... Testa, U. (2015). MiR-21 is overexpressed in NPM1-mutant acute myeloid leukemias. Leukemia Research, 39(2), 221-228. https://doi.org/10.1016/j.leukres.2014.11.001

MiR-21 is overexpressed in NPM1-mutant acute myeloid leukemias. / Riccioni, Roberta; Lulli, Valentina; Castelli, Germana; Biffoni, Mauro; Tiberio, Rosella; Pelosi, Elvira; Lo-Coco, Francesco; Testa, Ugo.

In: Leukemia Research, Vol. 39, No. 2, 01.02.2015, p. 221-228.

Research output: Contribution to journalArticle

Riccioni, R, Lulli, V, Castelli, G, Biffoni, M, Tiberio, R, Pelosi, E, Lo-Coco, F & Testa, U 2015, 'MiR-21 is overexpressed in NPM1-mutant acute myeloid leukemias', Leukemia Research, vol. 39, no. 2, pp. 221-228. https://doi.org/10.1016/j.leukres.2014.11.001
Riccioni R, Lulli V, Castelli G, Biffoni M, Tiberio R, Pelosi E et al. MiR-21 is overexpressed in NPM1-mutant acute myeloid leukemias. Leukemia Research. 2015 Feb 1;39(2):221-228. https://doi.org/10.1016/j.leukres.2014.11.001
Riccioni, Roberta ; Lulli, Valentina ; Castelli, Germana ; Biffoni, Mauro ; Tiberio, Rosella ; Pelosi, Elvira ; Lo-Coco, Francesco ; Testa, Ugo. / MiR-21 is overexpressed in NPM1-mutant acute myeloid leukemias. In: Leukemia Research. 2015 ; Vol. 39, No. 2. pp. 221-228.
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